FDPP-HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy

Pingping Liang; Jinjun Shao; Qianyun Tang; Weili Si; Qiang Wang; Qi Zhang; Xiaochen Dong

doi:10.1039/c7ra06551e

FDPP-HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy

Pingping Liang, Jinjun Shao, Qianyun Tang, Weili Si, Qiang Wang, Qi Zhang, Xiaochen Dong

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In clinics, for photodynamic therapy (PDT) it is challenging to achieve photosensitizers with properties of high singlet oxygen quantum yield, tumor targeting and fluorescence imaging simultaneously. Herein, a furan flanked diketopyrrolopyrrole (FDPP) molecule, with good singlet oxygen quantum yield (∼26%), is covalently connected to hyaluronic acid (HA) to obtain a water-soluble photosensitizer (FDPP-HA), which presents good specific targeting to HCT-116 tumor cells both in vitro and in vivo. FDPP-HA also exhibits excellent biocompatibility, low dark toxicity and high phototoxicity, which can effectively inhibit the tumor growth in vivo by PDT. The design of FDPP-HA in this work provides a general strategy for cancer target-specific fluorescence imaging and PDT.

Original language	English
Pages (from-to)	37369-37373
Number of pages	5
Journal	RSC Advances
Volume	7
Issue number	59
DOIs	https://doi.org/10.1039/c7ra06551e
State	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c7ra06551e

Cite this

@article{94a8bed649264c60bbebae532ee1fde7,

title = "FDPP-HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy",

abstract = "In clinics, for photodynamic therapy (PDT) it is challenging to achieve photosensitizers with properties of high singlet oxygen quantum yield, tumor targeting and fluorescence imaging simultaneously. Herein, a furan flanked diketopyrrolopyrrole (FDPP) molecule, with good singlet oxygen quantum yield (∼26%), is covalently connected to hyaluronic acid (HA) to obtain a water-soluble photosensitizer (FDPP-HA), which presents good specific targeting to HCT-116 tumor cells both in vitro and in vivo. FDPP-HA also exhibits excellent biocompatibility, low dark toxicity and high phototoxicity, which can effectively inhibit the tumor growth in vivo by PDT. The design of FDPP-HA in this work provides a general strategy for cancer target-specific fluorescence imaging and PDT.",

author = "Pingping Liang and Jinjun Shao and Qianyun Tang and Weili Si and Qiang Wang and Qi Zhang and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7ra06551e",

language = "英语",

volume = "7",

pages = "37369--37373",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "59",

}

TY - JOUR

T1 - FDPP-HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy

AU - Liang, Pingping

AU - Shao, Jinjun

AU - Tang, Qianyun

AU - Si, Weili

AU - Wang, Qiang

AU - Zhang, Qi

AU - Dong, Xiaochen

PY - 2017

Y1 - 2017

N2 - In clinics, for photodynamic therapy (PDT) it is challenging to achieve photosensitizers with properties of high singlet oxygen quantum yield, tumor targeting and fluorescence imaging simultaneously. Herein, a furan flanked diketopyrrolopyrrole (FDPP) molecule, with good singlet oxygen quantum yield (∼26%), is covalently connected to hyaluronic acid (HA) to obtain a water-soluble photosensitizer (FDPP-HA), which presents good specific targeting to HCT-116 tumor cells both in vitro and in vivo. FDPP-HA also exhibits excellent biocompatibility, low dark toxicity and high phototoxicity, which can effectively inhibit the tumor growth in vivo by PDT. The design of FDPP-HA in this work provides a general strategy for cancer target-specific fluorescence imaging and PDT.

AB - In clinics, for photodynamic therapy (PDT) it is challenging to achieve photosensitizers with properties of high singlet oxygen quantum yield, tumor targeting and fluorescence imaging simultaneously. Herein, a furan flanked diketopyrrolopyrrole (FDPP) molecule, with good singlet oxygen quantum yield (∼26%), is covalently connected to hyaluronic acid (HA) to obtain a water-soluble photosensitizer (FDPP-HA), which presents good specific targeting to HCT-116 tumor cells both in vitro and in vivo. FDPP-HA also exhibits excellent biocompatibility, low dark toxicity and high phototoxicity, which can effectively inhibit the tumor growth in vivo by PDT. The design of FDPP-HA in this work provides a general strategy for cancer target-specific fluorescence imaging and PDT.

UR - http://www.scopus.com/inward/record.url?scp=85026774601&partnerID=8YFLogxK

U2 - 10.1039/c7ra06551e

DO - 10.1039/c7ra06551e

M3 - 文章

AN - SCOPUS:85026774601

SN - 2046-2069

VL - 7

SP - 37369

EP - 37373

JO - RSC Advances

JF - RSC Advances

IS - 59

ER -

FDPP-HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this