Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

Yuancun Zhou; Jiacheng Zhu; Furong Gao; Ming Hu; Chengyuan Qian; Xin Wang; Xiaohui Wang

doi:10.1039/d4dt02188f

Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

Yuancun Zhou, Jiacheng Zhu, Furong Gao, Ming Hu, Chengyuan Qian, Xin Wang, Xiaohui Wang

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We herein report a “Fight Aggregation with Aggregation” (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(iii) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.

Original language	English
Pages (from-to)	14966-14970
Number of pages	5
Journal	Dalton Transactions
Volume	53
Issue number	36
DOIs	https://doi.org/10.1039/d4dt02188f
State	Published - 22 Aug 2024

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abstract = "We herein report a “Fight Aggregation with Aggregation” (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(iii) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.",

author = "Yuancun Zhou and Jiacheng Zhu and Furong Gao and Ming Hu and Chengyuan Qian and Xin Wang and Xiaohui Wang",

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T2 - remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

AU - Zhou, Yuancun

AU - Zhu, Jiacheng

AU - Gao, Furong

AU - Hu, Ming

AU - Qian, Chengyuan

AU - Wang, Xin

AU - Wang, Xiaohui

PY - 2024/8/22

Y1 - 2024/8/22

N2 - We herein report a “Fight Aggregation with Aggregation” (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(iii) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.

AB - We herein report a “Fight Aggregation with Aggregation” (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(iii) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.

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U2 - 10.1039/d4dt02188f

DO - 10.1039/d4dt02188f

M3 - 文章

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AN - SCOPUS:85202644859

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VL - 53

SP - 14966

EP - 14970

JO - Dalton Transactions

JF - Dalton Transactions

IS - 36

ER -

Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

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