Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application

Yi Zhou; Meng Meng Liu; Jing Yun Li; Min An Ye; Cheng Yao

doi:10.1016/j.dyepig.2018.05.053

Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application

Yi Zhou, Meng Meng Liu, Jing Yun Li, Min An Ye, Cheng Yao

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Fluoride and its derivatives are implicated in a variety of pathological and physiological conditions and hence play an important role in our daily life. Thus a fluorescent probe that enables the detection and imaging of fluoride in living species is highly demanded. In this study, three turn-on fluorescent probes (HPQF1∼HPQF3) were designed for detecting fluoride with their sensibilities verified by different steric hindrances around silyl ethers. The three HPQ-based probes could quantitatively detect fluoride anion in acetonitrile as well as in water. The fluorescent response time was only a few seconds in acetonitrile, and two different fluorescent sensing channels in acetonitrile (blue) and water (green) were observed by naked eyes. This work also provides a useful method to fluorescently image the presence of fluoride anions in both living cells and specific zebrafish organelles.

Original language	English
Pages (from-to)	277-284
Number of pages	8
Journal	Dyes and Pigments
Volume	158
DOIs	https://doi.org/10.1016/j.dyepig.2018.05.053
State	Published - Nov 2018

Keywords

Fluoride
In vivo imaging
Probe
Silyl ether
Steric hindrance

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10.1016/j.dyepig.2018.05.053

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title = "Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application",

abstract = "Fluoride and its derivatives are implicated in a variety of pathological and physiological conditions and hence play an important role in our daily life. Thus a fluorescent probe that enables the detection and imaging of fluoride in living species is highly demanded. In this study, three turn-on fluorescent probes (HPQF1∼HPQF3) were designed for detecting fluoride with their sensibilities verified by different steric hindrances around silyl ethers. The three HPQ-based probes could quantitatively detect fluoride anion in acetonitrile as well as in water. The fluorescent response time was only a few seconds in acetonitrile, and two different fluorescent sensing channels in acetonitrile (blue) and water (green) were observed by naked eyes. This work also provides a useful method to fluorescently image the presence of fluoride anions in both living cells and specific zebrafish organelles.",

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author = "Yi Zhou and Liu, {Meng Meng} and Li, {Jing Yun} and Ye, {Min An} and Cheng Yao",

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year = "2018",

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doi = "10.1016/j.dyepig.2018.05.053",

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T1 - Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application

AU - Zhou, Yi

AU - Liu, Meng Meng

AU - Li, Jing Yun

AU - Ye, Min An

AU - Yao, Cheng

PY - 2018/11

Y1 - 2018/11

N2 - Fluoride and its derivatives are implicated in a variety of pathological and physiological conditions and hence play an important role in our daily life. Thus a fluorescent probe that enables the detection and imaging of fluoride in living species is highly demanded. In this study, three turn-on fluorescent probes (HPQF1∼HPQF3) were designed for detecting fluoride with their sensibilities verified by different steric hindrances around silyl ethers. The three HPQ-based probes could quantitatively detect fluoride anion in acetonitrile as well as in water. The fluorescent response time was only a few seconds in acetonitrile, and two different fluorescent sensing channels in acetonitrile (blue) and water (green) were observed by naked eyes. This work also provides a useful method to fluorescently image the presence of fluoride anions in both living cells and specific zebrafish organelles.

AB - Fluoride and its derivatives are implicated in a variety of pathological and physiological conditions and hence play an important role in our daily life. Thus a fluorescent probe that enables the detection and imaging of fluoride in living species is highly demanded. In this study, three turn-on fluorescent probes (HPQF1∼HPQF3) were designed for detecting fluoride with their sensibilities verified by different steric hindrances around silyl ethers. The three HPQ-based probes could quantitatively detect fluoride anion in acetonitrile as well as in water. The fluorescent response time was only a few seconds in acetonitrile, and two different fluorescent sensing channels in acetonitrile (blue) and water (green) were observed by naked eyes. This work also provides a useful method to fluorescently image the presence of fluoride anions in both living cells and specific zebrafish organelles.

KW - Fluoride

KW - In vivo imaging

KW - Probe

KW - Silyl ether

KW - Steric hindrance

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DO - 10.1016/j.dyepig.2018.05.053

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SN - 0143-7208

VL - 158

SP - 277

EP - 284

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application

Abstract

Keywords

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