TY - JOUR
T1 - Highly enantioselective intermolecular alkylation of aldehydes with alcohols by cooperative catalysis of diarylprolinol silyl ether with Brønsted acid
AU - Xiao, Jian
AU - Zhao, Kai
AU - Loh, Teck Peng
PY - 2011/11/4
Y1 - 2011/11/4
N2 - Two cooperative systems: I/2,3,4-trihydroxybenzoic acid and I/TfOH effect highly enantioselective intermolecular α-alkylation of aldehydes. These systems afford functionalized aldehydes in high yields, and with excellent ee and de values with broad substrate scope (see scheme; R1=alkyl, R2,R3=aryl, or R2=ferrocenyl, R 3=phenyl, or R2=indolyl, R3=phenyl).
AB - Two cooperative systems: I/2,3,4-trihydroxybenzoic acid and I/TfOH effect highly enantioselective intermolecular α-alkylation of aldehydes. These systems afford functionalized aldehydes in high yields, and with excellent ee and de values with broad substrate scope (see scheme; R1=alkyl, R2,R3=aryl, or R2=ferrocenyl, R 3=phenyl, or R2=indolyl, R3=phenyl).
KW - alkylation
KW - brønsted acid
KW - cooperative catalysis
KW - enantioselectivty
KW - organocatalysis
UR - http://www.scopus.com/inward/record.url?scp=80155171614&partnerID=8YFLogxK
U2 - 10.1002/asia.201100692
DO - 10.1002/asia.201100692
M3 - 文章
AN - SCOPUS:80155171614
SN - 1861-4728
VL - 6
SP - 2890
EP - 2894
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
IS - 11
ER -