Improvement of toughness for the hyaluronic acid and adipic acid dihydrazide hydrogel by PEG

Xuebin Ma; Tingting Xu; Wei Chen; Rui Wang; Zheng Xu; Zhiwen Ye; Bo Chi

doi:10.1007/s12221-017-6986-1

Improvement of toughness for the hyaluronic acid and adipic acid dihydrazide hydrogel by PEG

Xuebin Ma, Tingting Xu, Wei Chen, Rui Wang, Zheng Xu, Zhiwen Ye, Bo Chi

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

New applications call for many new requirements. In order to improve the toughness of aldehyde hyaluronic acid (A-HA) and adipic acid dihydrazide (ADH) hydrogel, the poly(ethylene glycol) (PEG) was added. PEG content and molecular weight have little effect on the gelation time, and the composite hydrogels can form in situ within 20 seconds at room temperature. The press test showed that the hydrogels containing PEG possessed a better compression resistance, after pressed more than five times, the composite hydrogels could restore. Rheological properties were measured to evaluate the working ability and the effect of PEG on hydrogels. By analyzing the shear viscosity (η_γ=0.01), yield stress (σ₀) and threshold shear stress (σ_c), the addition of PEG can make the structure of composite hydrogels get loose and improve the shear resistance. Especially, PEG800 can enhance the antishear ability obviously. The amplitude sweep tests showed a broad linear viscoelastic region, indicating a wide processing range. In the meanwhile, we also found that PEG can improve the optical transmittance of xerogel evidently.

Original language	English
Pages (from-to)	817-824
Number of pages	8
Journal	Fibers and Polymers
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/s12221-017-6986-1
State	Published - 1 May 2017

Keywords

Antishear
Hyaluronic acid
Hydrogel
Poly(ethylene glycol)
Rheology

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title = "Improvement of toughness for the hyaluronic acid and adipic acid dihydrazide hydrogel by PEG",

abstract = "New applications call for many new requirements. In order to improve the toughness of aldehyde hyaluronic acid (A-HA) and adipic acid dihydrazide (ADH) hydrogel, the poly(ethylene glycol) (PEG) was added. PEG content and molecular weight have little effect on the gelation time, and the composite hydrogels can form in situ within 20 seconds at room temperature. The press test showed that the hydrogels containing PEG possessed a better compression resistance, after pressed more than five times, the composite hydrogels could restore. Rheological properties were measured to evaluate the working ability and the effect of PEG on hydrogels. By analyzing the shear viscosity (ηγ=0.01), yield stress (σ0) and threshold shear stress (σc), the addition of PEG can make the structure of composite hydrogels get loose and improve the shear resistance. Especially, PEG800 can enhance the antishear ability obviously. The amplitude sweep tests showed a broad linear viscoelastic region, indicating a wide processing range. In the meanwhile, we also found that PEG can improve the optical transmittance of xerogel evidently.",

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author = "Xuebin Ma and Tingting Xu and Wei Chen and Rui Wang and Zheng Xu and Zhiwen Ye and Bo Chi",

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AU - Ma, Xuebin

AU - Xu, Tingting

AU - Chen, Wei

AU - Wang, Rui

AU - Xu, Zheng

AU - Ye, Zhiwen

AU - Chi, Bo

PY - 2017/5/1

Y1 - 2017/5/1

N2 - New applications call for many new requirements. In order to improve the toughness of aldehyde hyaluronic acid (A-HA) and adipic acid dihydrazide (ADH) hydrogel, the poly(ethylene glycol) (PEG) was added. PEG content and molecular weight have little effect on the gelation time, and the composite hydrogels can form in situ within 20 seconds at room temperature. The press test showed that the hydrogels containing PEG possessed a better compression resistance, after pressed more than five times, the composite hydrogels could restore. Rheological properties were measured to evaluate the working ability and the effect of PEG on hydrogels. By analyzing the shear viscosity (ηγ=0.01), yield stress (σ0) and threshold shear stress (σc), the addition of PEG can make the structure of composite hydrogels get loose and improve the shear resistance. Especially, PEG800 can enhance the antishear ability obviously. The amplitude sweep tests showed a broad linear viscoelastic region, indicating a wide processing range. In the meanwhile, we also found that PEG can improve the optical transmittance of xerogel evidently.

AB - New applications call for many new requirements. In order to improve the toughness of aldehyde hyaluronic acid (A-HA) and adipic acid dihydrazide (ADH) hydrogel, the poly(ethylene glycol) (PEG) was added. PEG content and molecular weight have little effect on the gelation time, and the composite hydrogels can form in situ within 20 seconds at room temperature. The press test showed that the hydrogels containing PEG possessed a better compression resistance, after pressed more than five times, the composite hydrogels could restore. Rheological properties were measured to evaluate the working ability and the effect of PEG on hydrogels. By analyzing the shear viscosity (ηγ=0.01), yield stress (σ0) and threshold shear stress (σc), the addition of PEG can make the structure of composite hydrogels get loose and improve the shear resistance. Especially, PEG800 can enhance the antishear ability obviously. The amplitude sweep tests showed a broad linear viscoelastic region, indicating a wide processing range. In the meanwhile, we also found that PEG can improve the optical transmittance of xerogel evidently.

KW - Antishear

KW - Hyaluronic acid

KW - Hydrogel

KW - Poly(ethylene glycol)

KW - Rheology

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Improvement of toughness for the hyaluronic acid and adipic acid dihydrazide hydrogel by PEG

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