Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

Haixiao Fang; Riri Shi; Ding Chen; Yunwei Qu; Qiong Wu; Xuekang Yang; Xiaomei Lu; Cheng Wu Zhang; Lin Li; Kah Leong Lim

doi:10.1039/d1cc04744b

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

Haixiao Fang, Riri Shi, Ding Chen, Yunwei Qu, Qiong Wu, Xuekang Yang, Xiaomei Lu, Cheng Wu Zhang, Lin Li, Kah Leong Lim

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.

Original language	English
Pages (from-to)	11260-11263
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	85
DOIs	https://doi.org/10.1039/d1cc04744b
State	Published - 4 Nov 2021

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title = "Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging",

abstract = "MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.",

author = "Haixiao Fang and Riri Shi and Ding Chen and Yunwei Qu and Qiong Wu and Xuekang Yang and Xiaomei Lu and Zhang, {Cheng Wu} and Lin Li and Lim, {Kah Leong}",

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doi = "10.1039/d1cc04744b",

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T1 - Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

AU - Fang, Haixiao

AU - Shi, Riri

AU - Chen, Ding

AU - Qu, Yunwei

AU - Wu, Qiong

AU - Yang, Xuekang

AU - Lu, Xiaomei

AU - Zhang, Cheng Wu

AU - Li, Lin

AU - Lim, Kah Leong

PY - 2021/11/4

Y1 - 2021/11/4

N2 - MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.

AB - MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.

UR - http://www.scopus.com/inward/record.url?scp=85118451222&partnerID=8YFLogxK

U2 - 10.1039/d1cc04744b

DO - 10.1039/d1cc04744b

M3 - 文章

C2 - 34636370

AN - SCOPUS:85118451222

SN - 1359-7345

VL - 57

SP - 11260

EP - 11263

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

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