Iron-Catalyzed Synthesis of Pyridines from α,β-Unsaturated Ketoxime Acetates and N -Acetyl Enamides

Gaochen Xu; Huan Yan; Sai Zhang; Qinghuan Wu; Jindian Duan; Kai Guo

doi:10.1055/a-1679-7225

Iron-Catalyzed Synthesis of Pyridines from α,β-Unsaturated Ketoxime Acetates and N -Acetyl Enamides

Gaochen Xu, Huan Yan, Sai Zhang, Qinghuan Wu, Jindian Duan, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A new method of FeCl₂-catalyzed [4+2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity, and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.

Original language	English
Pages (from-to)	283-287
Number of pages	5
Journal	Synlett
Volume	33
Issue number	3
DOIs	https://doi.org/10.1055/a-1679-7225
State	Published - Feb 2022

Keywords

N -acetyl enamides
annulation
iron
ketoxime acetates
pyridines

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10.1055/a-1679-7225

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title = "Iron-Catalyzed Synthesis of Pyridines from α,β-Unsaturated Ketoxime Acetates and N -Acetyl Enamides",

abstract = "A new method of FeCl2-catalyzed [4+2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity, and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.",

keywords = "N -acetyl enamides, annulation, iron, ketoxime acetates, pyridines",

author = "Gaochen Xu and Huan Yan and Sai Zhang and Qinghuan Wu and Jindian Duan and Kai Guo",

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TY - JOUR

T1 - Iron-Catalyzed Synthesis of Pyridines from α,β-Unsaturated Ketoxime Acetates and N -Acetyl Enamides

AU - Xu, Gaochen

AU - Yan, Huan

AU - Zhang, Sai

AU - Wu, Qinghuan

AU - Duan, Jindian

AU - Guo, Kai

PY - 2022/2

Y1 - 2022/2

N2 - A new method of FeCl2-catalyzed [4+2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity, and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.

AB - A new method of FeCl2-catalyzed [4+2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity, and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.

KW - N -acetyl enamides

KW - annulation

KW - iron

KW - ketoxime acetates

KW - pyridines

UR - http://www.scopus.com/inward/record.url?scp=85120332241&partnerID=8YFLogxK

U2 - 10.1055/a-1679-7225

DO - 10.1055/a-1679-7225

M3 - 文章

AN - SCOPUS:85120332241

SN - 0936-5214

VL - 33

SP - 283

EP - 287

JO - Synlett

JF - Synlett

IS - 3

ER -

Iron-Catalyzed Synthesis of Pyridines from α,β-Unsaturated Ketoxime Acetates and N -Acetyl Enamides

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Keywords

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