Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase

Yan Ding, Xiao Ni, Mengjie Gu, Shuang Li, He Huang, Yi Hu

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A screening of using different lipases to catalyze the Knoevenagel reaction was realized, and lipase lipoprotein (LPL) from Aspergillus niger showed the best catalytic performance. The reaction conditions including solvent, enzyme loading, and temperature were screened to improve the reaction efficiency. Various kinds of substrates were investigated, and almost all the target products were obtained in good to excellent yields (76-98%) with Z configuration exclusively. This procedure provides a novel, green and efficient method for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalCatalysis Communications
Volume64
DOIs
StatePublished - 5 Apr 2015

Keywords

  • Active methylene compounds
  • Aromatic aldehydes
  • Knoevenagel condensation
  • Lipases

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