Metal-Free Radical-Triggered Selenosulfonation of 1,7-Enynes for the Rapid Synthesis of 3,4-Dihydroquinolin-2(1H)-ones in Batch and Flow

A novel three-component selenosulfonation of 1,7-enynes with sulfinic acids and diphenyl diselenides for the formation of multifunctional 3,4-dihydroquinolin-2(1H)-ones was developed in batch and flow. This room-temperature protocol provides a highly efficient approach to diverse selenosulfones in moderate to excellent yields and with a broad scope of substrates. It should provide a potential synthesis method for the construction of diverse and meaningful 3,4-dihydroquinolin-2(1H)-ones derivatives in the fields of pharmaceutical and biological chemistry. Additionally, an obvious acceleration (20 h to 43 s) was obtained under micro flow conditions. (Figure presented.).