Abstract
Here, we report a highly efficient catalytic species generated from Ph3C+[B(C6F5)4]− by the water mediated Friedel-Crafts type reaction of indoles with carbonyl compounds to afford 3,3′-bisindolylmethanes (BIMs). This scalable method is applicable to a wide variety of carbonyl compounds, including unprotected sugar molecules and carbonyl compounds derived from drugs and natural products.
Original language | English |
---|---|
Pages (from-to) | 5154-5159 |
Number of pages | 6 |
Journal | Organic Chemistry Frontiers |
Volume | 9 |
Issue number | 19 |
DOIs | |
State | Published - 4 Aug 2022 |
Externally published | Yes |