Metal-free synthesis of 3,3′-bisindolylmethanes in water using Ph3C+[B(C6F5)4] as the pre-catalyst

Zhenguo Zhang, Liang Ji, Xiaoxiao Liu, Zhihong Li, Yongheng Lv, Zhenhua Jia, Teck Peng Loh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Here, we report a highly efficient catalytic species generated from Ph3C+[B(C6F5)4] by the water mediated Friedel-Crafts type reaction of indoles with carbonyl compounds to afford 3,3′-bisindolylmethanes (BIMs). This scalable method is applicable to a wide variety of carbonyl compounds, including unprotected sugar molecules and carbonyl compounds derived from drugs and natural products.

Original languageEnglish
Pages (from-to)5154-5159
Number of pages6
JournalOrganic Chemistry Frontiers
Volume9
Issue number19
DOIs
StatePublished - 4 Aug 2022
Externally publishedYes

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