Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow

Songjie Shi; Li Wan; Xiaoning Sun; Jiawei Zhang; Kai Guo

doi:10.1002/cjoc.201600606

Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow

Songjie Shi, Li Wan, Xiaoning Sun, Jiawei Zhang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.

Original language	English
Pages (from-to)	410-414
Number of pages	5
Journal	Chinese Journal of Chemistry
Volume	35
Issue number	4
DOIs	https://doi.org/10.1002/cjoc.201600606
State	Published - Apr 2017

Keywords

azoxybenzenes
chloronitrobenzenes
continuous flow
methoxylation
sodium methoxide

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10.1002/cjoc.201600606

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title = "Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow",

abstract = "A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.",

keywords = "azoxybenzenes, chloronitrobenzenes, continuous flow, methoxylation, sodium methoxide",

author = "Songjie Shi and Li Wan and Xiaoning Sun and Jiawei Zhang and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2017 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

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T1 - Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow

AU - Shi, Songjie

AU - Wan, Li

AU - Sun, Xiaoning

AU - Zhang, Jiawei

AU - Guo, Kai

PY - 2017/4

Y1 - 2017/4

N2 - A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.

AB - A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.

KW - azoxybenzenes

KW - chloronitrobenzenes

KW - continuous flow

KW - methoxylation

KW - sodium methoxide

UR - http://www.scopus.com/inward/record.url?scp=85014547858&partnerID=8YFLogxK

U2 - 10.1002/cjoc.201600606

DO - 10.1002/cjoc.201600606

M3 - 文章

AN - SCOPUS:85014547858

SN - 1001-604X

VL - 35

SP - 410

EP - 414

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 4

ER -

Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow

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Keywords

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