Multifunctional fluorescence/magnetic composite microspheres for cell tracking and drug targeting usage

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Abstract

A supermagnetic iron oxide (SPIO) microspheres is emerging as an ideal tool for cell tracking and drug targeting delivery. However, its low intracellular labeling efficiency has limited the potential usage. We have developed CdTe-incorporated CMCH/SiO2-coated core-shell composite microspheres, Fe3O4@SiO2@CMCH/CdTe (FSCC), with diameters of 210 nm, as a multifunctional magnetic vector that can efficiently orient targeted cells and visualize easily by UV. The multifunctional nanoparticles were injected into nude mice, and the potential usage as a dual modality imaging agent in vivo was demonstrated by MRI and UV light.

Original languageEnglish
Title of host publication2010 Symposium on Photonics and Optoelectronic, SOPO 2010 - Proceedings
DOIs
StatePublished - 2010
EventInternational Symposium on Photonics and Optoelectronics, SOPO 2010 - Chengdu, China
Duration: 19 Jun 201021 Jun 2010

Publication series

Name2010 Symposium on Photonics and Optoelectronic, SOPO 2010 - Proceedings

Conference

ConferenceInternational Symposium on Photonics and Optoelectronics, SOPO 2010
Country/TerritoryChina
CityChengdu
Period19/06/1021/06/10

Keywords

  • Cell track
  • Drug target
  • Fluorescence
  • Magnetic
  • Microspheres

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