TY - JOUR
T1 - Multifunctional Hydrogel Electronics for Synergistic Therapy and Visual Monitoring in Wound Healing
AU - Ji, Yun Liang
AU - Zhang, Yizhou
AU - Lu, Jingqi
AU - Gao, Fan
AU - Lv, Xinyi
AU - Qu, Xinyu
AU - Zhu, Guoyin
AU - Tian, Tian
AU - Pang, Huan
AU - Tian, Yu
AU - Dong, Xiaochen
N1 - Publisher Copyright:
© 2025 Wiley-VCH GmbH.
PY - 2025/4/4
Y1 - 2025/4/4
N2 - To overcome the limitations of precise monitoring and inefficient wound exudate management in wound healing, an advanced multifunctional hydrogel electronics (MHE) platform based on MXene@MOF/Fe3O4@C photonic crystal hydrogel is developed. This platform combines optical/electrical sensing, synergistic therapy, and real-time visual monitoring into a single, efficient system, offering a comprehensive solution for wound healing. Under photothermal stimulation, the hydrogel releases metal ions that generate hydroxyl radicals, effectively eliminating antibiotic-resistant bacteria. Beyond its antibacterial efficacy, this system offers unprecedented real-time monitoring through temperature-responsive visualization, while structural color changes upon wound exudate absorption provide a clear indication for dressing replacement. By integrating these functionalities, MHE platform allows for precise control of the therapeutic process, significantly improving wound healing and treatment monitoring. The platform's optical/electrical sensing capabilities further broaden its potential applications across other biomedical fields. This breakthrough technology provides clinicians with a powerful tool to optimize therapeutic outcomes, marking a major advancement in wound care and biomedical applications.
AB - To overcome the limitations of precise monitoring and inefficient wound exudate management in wound healing, an advanced multifunctional hydrogel electronics (MHE) platform based on MXene@MOF/Fe3O4@C photonic crystal hydrogel is developed. This platform combines optical/electrical sensing, synergistic therapy, and real-time visual monitoring into a single, efficient system, offering a comprehensive solution for wound healing. Under photothermal stimulation, the hydrogel releases metal ions that generate hydroxyl radicals, effectively eliminating antibiotic-resistant bacteria. Beyond its antibacterial efficacy, this system offers unprecedented real-time monitoring through temperature-responsive visualization, while structural color changes upon wound exudate absorption provide a clear indication for dressing replacement. By integrating these functionalities, MHE platform allows for precise control of the therapeutic process, significantly improving wound healing and treatment monitoring. The platform's optical/electrical sensing capabilities further broaden its potential applications across other biomedical fields. This breakthrough technology provides clinicians with a powerful tool to optimize therapeutic outcomes, marking a major advancement in wound care and biomedical applications.
KW - MOF
KW - flexible electronics
KW - flexible sensors
KW - hydrogel sensors
KW - photothermal-enhanced chemodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=85217364301&partnerID=8YFLogxK
U2 - 10.1002/adhm.202404723
DO - 10.1002/adhm.202404723
M3 - 文章
AN - SCOPUS:85217364301
SN - 2192-2640
VL - 14
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 9
M1 - 2404723
ER -