TY - JOUR
T1 - Multifunctional polysaccharide hydrogels for skin wound healing prepared by photoinitiator-free crosslinking
AU - Mao, Hongli
AU - Zhao, Shijia
AU - He, Yuxin
AU - Feng, Miao
AU - Wu, Lihuang
AU - He, Yiyan
AU - Gu, Zhongwei
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Photocrosslinked hydrogels show great potential as dressings for skin wound healing. However, most current hydrogels suffer from poor adhesion, toxic photoinitiators, and insufficient versatility. Therefore, developing novel hydrogel dressings with appropriate properties is of great importance to accelerate the wound healing process. In this study, we developed a polysaccharide-based dual-network hydrogel consisting of azide-functionalized carboxymethyl chitosan and o-nitrobenzyl-modified hyaluronic acid (CMC-AZ/HA-NB). The hydrogel showed excellent mechanical, tissue adhesion, and water retention properties. Controllable in situ photocrosslinking was carried out without photoinitiator, avoiding issues associated with the cytotoxicity of photoinitiators. An antibacterial agent-loaded hydrogel (CMC-AZ/HA-NB@D) showed enhanced antibacterial properties. In addition, the CMC-AZ/HA-NB@D hydrogel promoted collagen deposition and vascular formation, as well as reducing the expression of pro-inflammatory factors, thereby accelerating the wound healing process and improving skin regeneration. The present results highlight the promising potential of multifunctional photoinitiator-free polysaccharide hydrogels for application in wound dressings.
AB - Photocrosslinked hydrogels show great potential as dressings for skin wound healing. However, most current hydrogels suffer from poor adhesion, toxic photoinitiators, and insufficient versatility. Therefore, developing novel hydrogel dressings with appropriate properties is of great importance to accelerate the wound healing process. In this study, we developed a polysaccharide-based dual-network hydrogel consisting of azide-functionalized carboxymethyl chitosan and o-nitrobenzyl-modified hyaluronic acid (CMC-AZ/HA-NB). The hydrogel showed excellent mechanical, tissue adhesion, and water retention properties. Controllable in situ photocrosslinking was carried out without photoinitiator, avoiding issues associated with the cytotoxicity of photoinitiators. An antibacterial agent-loaded hydrogel (CMC-AZ/HA-NB@D) showed enhanced antibacterial properties. In addition, the CMC-AZ/HA-NB@D hydrogel promoted collagen deposition and vascular formation, as well as reducing the expression of pro-inflammatory factors, thereby accelerating the wound healing process and improving skin regeneration. The present results highlight the promising potential of multifunctional photoinitiator-free polysaccharide hydrogels for application in wound dressings.
KW - Adhesive
KW - Antibacterial
KW - Dual-network hydrogel
KW - Photoinitiator-free
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85124609541&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2022.119254
DO - 10.1016/j.carbpol.2022.119254
M3 - 文章
C2 - 35287868
AN - SCOPUS:85124609541
SN - 0144-8617
VL - 285
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 119254
ER -