Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

Meijiao Cao; Haiyan Chen; Dan Chen; Zhiqiang Xu; Sheng Hua Liu; Xiaoqiang Chen; Jun Yin

doi:10.1039/c5cc08328a

Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

Meijiao Cao, Haiyan Chen, Dan Chen, Zhiqiang Xu, Sheng Hua Liu, Xiaoqiang Chen, Jun Yin

College of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

A novel naphthalimide-based fluorescent probe employing a sulfonamide unit as a thiol-responsive group is reported. It is capable of efficiently distinguishing GSH from cysteine and homocysteine. Bioimaging shows that it has high selectivity in living cells and can visualize the level of GSH in lysosomes. It is worth mentioning that different groups on the imide unit can affect the selectivity and reaction dynamics of the probe towards thiols.

Original language	English
Pages (from-to)	721-724
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	4
DOIs	https://doi.org/10.1039/c5cc08328a
State	Published - 2016

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title = "Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells",

abstract = "A novel naphthalimide-based fluorescent probe employing a sulfonamide unit as a thiol-responsive group is reported. It is capable of efficiently distinguishing GSH from cysteine and homocysteine. Bioimaging shows that it has high selectivity in living cells and can visualize the level of GSH in lysosomes. It is worth mentioning that different groups on the imide unit can affect the selectivity and reaction dynamics of the probe towards thiols.",

author = "Meijiao Cao and Haiyan Chen and Dan Chen and Zhiqiang Xu and Liu, {Sheng Hua} and Xiaoqiang Chen and Jun Yin",

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AU - Cao, Meijiao

AU - Chen, Haiyan

AU - Chen, Dan

AU - Xu, Zhiqiang

AU - Liu, Sheng Hua

AU - Chen, Xiaoqiang

AU - Yin, Jun

PY - 2016

Y1 - 2016

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AB - A novel naphthalimide-based fluorescent probe employing a sulfonamide unit as a thiol-responsive group is reported. It is capable of efficiently distinguishing GSH from cysteine and homocysteine. Bioimaging shows that it has high selectivity in living cells and can visualize the level of GSH in lysosomes. It is worth mentioning that different groups on the imide unit can affect the selectivity and reaction dynamics of the probe towards thiols.

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M3 - 文章

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AN - SCOPUS:84969308161

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ER -

Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

Abstract

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