TY - JOUR
T1 - Near-Infrared Light-Harvesting Fullerene-Based Nanoparticles for Promoted Synergetic Tumor Phototheranostics
AU - Shi, Huaxia
AU - Gu, Rui
AU - Xu, Wenjing
AU - Huang, Han
AU - Xue, Lei
AU - Wang, Wenjun
AU - Zhang, Yewei
AU - Si, Weili
AU - Dong, Xiaochen
N1 - Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2019/12/4
Y1 - 2019/12/4
N2 - A synergetic phototheranostic system, combining diagnostic photo-imaging and phototherapies [such as photothermal therapy and photodynamic therapy (PDT)], shows great potential in today's tumor precise therapy. Herein, we fabricate near-infrared (NIR) light-harvesting fullerene-based nanoparticles (DAF NPs) for photoacoustic (PA) imaging-guided synergetic tumor photothermal and PDT. The fullerene derivatives (DAF) absorbing in the NIR region have been synthesized by conjugating NIR-Absorbing antenna with fullerene. In addition, DAF NPs with good biocompatibility have been fabricated via a nanoprecipitation approach. The as-prepared DAF NPs can accumulate and generate PA signals around the tumor site 6 h post injection via enhanced permeability and retention effect in vivo. More importantly, the DAF NPs exhibit better reactive oxygen species and heat generation efficacy compared with fullerene and antenna nanoparticles (DA NPs), respectively. Further in vitro and in vivo studies demonstrate that DAF NPs can effectively inhibit tumor growth through synergetic photodynamic and photothermal therapies, which provides a new sight of photosensitizer design for enhanced cancer phototheranostics.
AB - A synergetic phototheranostic system, combining diagnostic photo-imaging and phototherapies [such as photothermal therapy and photodynamic therapy (PDT)], shows great potential in today's tumor precise therapy. Herein, we fabricate near-infrared (NIR) light-harvesting fullerene-based nanoparticles (DAF NPs) for photoacoustic (PA) imaging-guided synergetic tumor photothermal and PDT. The fullerene derivatives (DAF) absorbing in the NIR region have been synthesized by conjugating NIR-Absorbing antenna with fullerene. In addition, DAF NPs with good biocompatibility have been fabricated via a nanoprecipitation approach. The as-prepared DAF NPs can accumulate and generate PA signals around the tumor site 6 h post injection via enhanced permeability and retention effect in vivo. More importantly, the DAF NPs exhibit better reactive oxygen species and heat generation efficacy compared with fullerene and antenna nanoparticles (DA NPs), respectively. Further in vitro and in vivo studies demonstrate that DAF NPs can effectively inhibit tumor growth through synergetic photodynamic and photothermal therapies, which provides a new sight of photosensitizer design for enhanced cancer phototheranostics.
KW - DAF nanoparticles
KW - photoacoustic imaging
KW - photodynamic therapy
KW - photothermal therapy
KW - synergetic cancer treatment
UR - http://www.scopus.com/inward/record.url?scp=85075617120&partnerID=8YFLogxK
U2 - 10.1021/acsami.9b17716
DO - 10.1021/acsami.9b17716
M3 - 文章
C2 - 31702130
AN - SCOPUS:85075617120
SN - 1944-8244
VL - 11
SP - 44970
EP - 44977
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 48
ER -
