Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides

Jing Ao Ren; Jin He Na; Chao Gui; Chengping Miao; Xue Qiang Chu; Mengtao Ma; Hao Xu; Xiaocong Zhou; Zhi Liang Shen

doi:10.1021/acs.orglett.3c02000

Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides

Jing Ao Ren, Jin He Na, Chao Gui, Chengping Miao, Xue Qiang Chu, Mengtao Ma, Hao Xu, Xiaocong Zhou, Zhi Liang Shen

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A nickel-catalyzed direct cross-coupling of unactivated aryl fluorides with aryl bromides is realized. The one-pot reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeds effectively via C-F bond cleavage at room temperature in THF in the presence of the phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.

Original language	English
Pages (from-to)	5525-5529
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	29
DOIs	https://doi.org/10.1021/acs.orglett.3c02000
State	Published - 28 Jul 2023

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title = "Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides",

abstract = "A nickel-catalyzed direct cross-coupling of unactivated aryl fluorides with aryl bromides is realized. The one-pot reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeds effectively via C-F bond cleavage at room temperature in THF in the presence of the phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.",

author = "Ren, {Jing Ao} and Na, {Jin He} and Chao Gui and Chengping Miao and Chu, {Xue Qiang} and Mengtao Ma and Hao Xu and Xiaocong Zhou and Shen, {Zhi Liang}",

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doi = "10.1021/acs.orglett.3c02000",

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TY - JOUR

T1 - Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides

AU - Ren, Jing Ao

AU - Na, Jin He

AU - Gui, Chao

AU - Miao, Chengping

AU - Chu, Xue Qiang

AU - Ma, Mengtao

AU - Xu, Hao

AU - Zhou, Xiaocong

AU - Shen, Zhi Liang

PY - 2023/7/28

Y1 - 2023/7/28

N2 - A nickel-catalyzed direct cross-coupling of unactivated aryl fluorides with aryl bromides is realized. The one-pot reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeds effectively via C-F bond cleavage at room temperature in THF in the presence of the phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.

AB - A nickel-catalyzed direct cross-coupling of unactivated aryl fluorides with aryl bromides is realized. The one-pot reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeds effectively via C-F bond cleavage at room temperature in THF in the presence of the phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.

UR - http://www.scopus.com/inward/record.url?scp=85166362546&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.3c02000

DO - 10.1021/acs.orglett.3c02000

M3 - 文章

C2 - 37459275

AN - SCOPUS:85166362546

SN - 1523-7060

VL - 25

SP - 5525

EP - 5529

JO - Organic Letters

JF - Organic Letters

IS - 29

ER -

Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides

Abstract

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