Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study

Li Ying Zhu; Xiao Qin Yan; Hong Man Zhang; Shan Jing Yao; Ling Jiang

doi:10.1007/s11814-015-0007-0

Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study

Li Ying Zhu, Xiao Qin Yan, Hong Man Zhang, Shan Jing Yao, Ling Jiang

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.

Original language	English
Pages (from-to)	369-372
Number of pages	4
Journal	Korean Journal of Chemical Engineering
Volume	32
Issue number	3
DOIs	https://doi.org/10.1007/s11814-015-0007-0
State	Published - Mar 2015

Keywords

Chitosan
Double-walled Microshperes
In Vitro Drug Release
Sodium Cellulose Sulfate
Sodium Tripolyphosphate

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10.1007/s11814-015-0007-0

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title = "Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study",

abstract = "A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.",

keywords = "Chitosan, Double-walled Microshperes, In Vitro Drug Release, Sodium Cellulose Sulfate, Sodium Tripolyphosphate",

author = "Zhu, {Li Ying} and Yan, {Xiao Qin} and Zhang, {Hong Man} and Yao, {Shan Jing} and Ling Jiang",

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doi = "10.1007/s11814-015-0007-0",

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T1 - Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate

T2 - Preparation, characterization and in vitro release study

AU - Zhu, Li Ying

AU - Yan, Xiao Qin

AU - Zhang, Hong Man

AU - Yao, Shan Jing

AU - Jiang, Ling

PY - 2015/3

Y1 - 2015/3

N2 - A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.

AB - A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.

KW - Chitosan

KW - Double-walled Microshperes

KW - In Vitro Drug Release

KW - Sodium Cellulose Sulfate

KW - Sodium Tripolyphosphate

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Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study

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Keywords

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