Novel turn-on fluorescence sensor for detection and imaging of endogenous H2S induced by sodium nitroprusside

Li Wang; Wenge Yang; Yiyi Song; Yonghong Hu

doi:10.1016/j.saa.2020.118775

Novel turn-on fluorescence sensor for detection and imaging of endogenous H₂S induced by sodium nitroprusside

Li Wang, Wenge Yang, Yiyi Song, Yonghong Hu

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Currently, fluorescence analysis method has a good application in the detection and imaging of biomarkers and has become an important analytical method. Although there are many fluorescent probes for detecting hydrogen sulfide(H₂S), they are mostly based on fluorophores which already existed, such as 1,8-naphthalimide, coumarin, rhodamine and their derivatives. Here, a new type of fluorescent molecule (BOTD) was synthesized and applied to the detection of H₂S. The probe BOTD could quickly and sensitively detect H₂S and turn on fluorescence. Moreover, the probe BOTD was successfully applied to the detection of exogenous and endogenous H₂S in living cells, and may be expected to become a research tool for studying H₂S-induced drugs.

Original language	English
Article number	118775
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	243
DOIs	https://doi.org/10.1016/j.saa.2020.118775
State	Published - 15 Dec 2020

Keywords

Bioimaging
Fluorescent probe
HS-induced drug
Hydrogen sulfide

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10.1016/j.saa.2020.118775

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title = "Novel turn-on fluorescence sensor for detection and imaging of endogenous H2S induced by sodium nitroprusside",

abstract = "Currently, fluorescence analysis method has a good application in the detection and imaging of biomarkers and has become an important analytical method. Although there are many fluorescent probes for detecting hydrogen sulfide(H2S), they are mostly based on fluorophores which already existed, such as 1,8-naphthalimide, coumarin, rhodamine and their derivatives. Here, a new type of fluorescent molecule (BOTD) was synthesized and applied to the detection of H2S. The probe BOTD could quickly and sensitively detect H2S and turn on fluorescence. Moreover, the probe BOTD was successfully applied to the detection of exogenous and endogenous H2S in living cells, and may be expected to become a research tool for studying H2S-induced drugs.",

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T1 - Novel turn-on fluorescence sensor for detection and imaging of endogenous H2S induced by sodium nitroprusside

AU - Wang, Li

AU - Yang, Wenge

AU - Song, Yiyi

AU - Hu, Yonghong

PY - 2020/12/15

Y1 - 2020/12/15

N2 - Currently, fluorescence analysis method has a good application in the detection and imaging of biomarkers and has become an important analytical method. Although there are many fluorescent probes for detecting hydrogen sulfide(H2S), they are mostly based on fluorophores which already existed, such as 1,8-naphthalimide, coumarin, rhodamine and their derivatives. Here, a new type of fluorescent molecule (BOTD) was synthesized and applied to the detection of H2S. The probe BOTD could quickly and sensitively detect H2S and turn on fluorescence. Moreover, the probe BOTD was successfully applied to the detection of exogenous and endogenous H2S in living cells, and may be expected to become a research tool for studying H2S-induced drugs.

AB - Currently, fluorescence analysis method has a good application in the detection and imaging of biomarkers and has become an important analytical method. Although there are many fluorescent probes for detecting hydrogen sulfide(H2S), they are mostly based on fluorophores which already existed, such as 1,8-naphthalimide, coumarin, rhodamine and their derivatives. Here, a new type of fluorescent molecule (BOTD) was synthesized and applied to the detection of H2S. The probe BOTD could quickly and sensitively detect H2S and turn on fluorescence. Moreover, the probe BOTD was successfully applied to the detection of exogenous and endogenous H2S in living cells, and may be expected to become a research tool for studying H2S-induced drugs.

KW - Bioimaging

KW - Fluorescent probe

KW - HS-induced drug

KW - Hydrogen sulfide

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DO - 10.1016/j.saa.2020.118775

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SN - 1386-1425

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JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

M1 - 118775

ER -

Novel turn-on fluorescence sensor for detection and imaging of endogenous H₂S induced by sodium nitroprusside

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