Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Yi Hu; Zhen Chu Chen; Zhang Gao Le; Qin Guo Zheng

doi:10.1081/SCC-200032526

Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Yi Hu, Zhen Chu Chen, Zhang Gao Le, Qin Guo Zheng

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF₄) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF₆) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

Original language	English
Pages (from-to)	3801-3806
Number of pages	6
Journal	Synthetic Communications
Volume	34
Issue number	20
DOIs	https://doi.org/10.1081/SCC-200032526
State	Published - 2004
Externally published	Yes

Keywords

2-Aminothiophene
Gewald reaction
Ionic liquids
Knoevenagel condensation

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10.1081/SCC-200032526

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title = "Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate",

abstract = "Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.",

keywords = "2-Aminothiophene, Gewald reaction, Ionic liquids, Knoevenagel condensation",

author = "Yi Hu and Chen, {Zhen Chu} and Le, {Zhang Gao} and Zheng, {Qin Guo}",

year = "2004",

doi = "10.1081/SCC-200032526",

language = "英语",

volume = "34",

pages = "3801--3806",

journal = "Synthetic Communications",

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TY - JOUR

T1 - Organic reactions in ionic liquids

T2 - Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

AU - Hu, Yi

AU - Chen, Zhen Chu

AU - Le, Zhang Gao

AU - Zheng, Qin Guo

PY - 2004

Y1 - 2004

N2 - Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

AB - Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

KW - 2-Aminothiophene

KW - Gewald reaction

KW - Ionic liquids

KW - Knoevenagel condensation

UR - http://www.scopus.com/inward/record.url?scp=7444231576&partnerID=8YFLogxK

U2 - 10.1081/SCC-200032526

DO - 10.1081/SCC-200032526

M3 - 文章

AN - SCOPUS:7444231576

SN - 0039-7911

VL - 34

SP - 3801

EP - 3806

JO - Synthetic Communications

JF - Synthetic Communications

IS - 20

ER -

Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Abstract

Keywords

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