Palladium Catalyzed Direct Ortho C-H Acylation of 4-Phenylquinazoline Using Methylarenes as Acylation Reagents

Tongtong Deng; Shan Hu; Xianyu Ying; Hui Wang; Hongjun Zhu

doi:10.1002/ajoc.202400394

Palladium Catalyzed Direct Ortho C-H Acylation of 4-Phenylquinazoline Using Methylarenes as Acylation Reagents

Tongtong Deng, Shan Hu, Xianyu Ying, Hui Wang, Hongjun Zhu

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

Abstract

A simple ortho-acylation of 4-phenylquinazoline by a Pd-catalyzed oxidative C−H activation was developed, with moderate yields, in which no prefunctionalized methylarenes were used as acylation reagents. Moreover, this methodology tolerates a wide range of functional groups. Radical scavenging experiments indicate that the acylation involves a benzoyl radical pathway.

Original language	English
Article number	e202400394
Journal	Asian Journal of Organic Chemistry
Volume	13
Issue number	12
DOIs	https://doi.org/10.1002/ajoc.202400394
State	Published - Dec 2024

Keywords

Acylation
C−H Activation
Methylarenes
Palladium
Quinazoline

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10.1002/ajoc.202400394

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abstract = "A simple ortho-acylation of 4-phenylquinazoline by a Pd-catalyzed oxidative C−H activation was developed, with moderate yields, in which no prefunctionalized methylarenes were used as acylation reagents. Moreover, this methodology tolerates a wide range of functional groups. Radical scavenging experiments indicate that the acylation involves a benzoyl radical pathway.",

keywords = "Acylation, C−H Activation, Methylarenes, Palladium, Quinazoline",

author = "Tongtong Deng and Shan Hu and Xianyu Ying and Hui Wang and Hongjun Zhu",

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AU - Deng, Tongtong

AU - Hu, Shan

AU - Ying, Xianyu

AU - Wang, Hui

AU - Zhu, Hongjun

PY - 2024/12

Y1 - 2024/12

N2 - A simple ortho-acylation of 4-phenylquinazoline by a Pd-catalyzed oxidative C−H activation was developed, with moderate yields, in which no prefunctionalized methylarenes were used as acylation reagents. Moreover, this methodology tolerates a wide range of functional groups. Radical scavenging experiments indicate that the acylation involves a benzoyl radical pathway.

AB - A simple ortho-acylation of 4-phenylquinazoline by a Pd-catalyzed oxidative C−H activation was developed, with moderate yields, in which no prefunctionalized methylarenes were used as acylation reagents. Moreover, this methodology tolerates a wide range of functional groups. Radical scavenging experiments indicate that the acylation involves a benzoyl radical pathway.

KW - Acylation

KW - C−H Activation

KW - Methylarenes

KW - Palladium

KW - Quinazoline

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U2 - 10.1002/ajoc.202400394

DO - 10.1002/ajoc.202400394

M3 - 文章

AN - SCOPUS:85207682248

SN - 2193-5807

VL - 13

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 12

M1 - e202400394

ER -

Palladium Catalyzed Direct Ortho C-H Acylation of 4-Phenylquinazoline Using Methylarenes as Acylation Reagents

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Keywords

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