Perspectives for the microbial production of ethyl acetate

Shangjie Zhang; Feng Guo; Wei Yan; Weiliang Dong; Jie Zhou; Wenming Zhang; Fengxue Xin; Min Jiang

doi:10.1007/s00253-020-10756-z

Perspectives for the microbial production of ethyl acetate

Shangjie Zhang, Feng Guo, Wei Yan, Weiliang Dong, Jie Zhou, Wenming Zhang, Fengxue Xin, Min Jiang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Abstract: Ethyl acetate is one of the short-chain esters and widely used in the food, beverage, and solvent areas. The ethyl acetate production currently proceeds through unsustainable and energy intensive processes, which are based on natural gas and crude oil. Microbial conversion of biomass-derived sugars into ethyl acetate may provide a sustainable alternative. In this review, the perspectives of bio-catalyzing ethanol and acetic acid to ethyl acetate using lipases in vitro was introduced. Besides, the crucial elements for high yield of ethyl acetate in fermentation was expounded. Also, metabolic engineering in yeasts to product ethyl acetate in vivo using alcohol acyl transferases (AAT) was discussed. Key points: •The accumulation of acetyl-CoA is crucial for synthesizing ethyl acetate in vivo; AAT-mediated metabolic engineering could efficiently improve ethyl acetate production.

Original language	English
Pages (from-to)	7239-7245
Number of pages	7
Journal	Applied Microbiology and Biotechnology
Volume	104
Issue number	17
DOIs	https://doi.org/10.1007/s00253-020-10756-z
State	Published - 1 Sep 2020

Keywords

Alcohol acyl transferases
Bioethanol
Ethyl acetate
Lignocellulose
Lipases

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title = "Perspectives for the microbial production of ethyl acetate",

abstract = "Abstract: Ethyl acetate is one of the short-chain esters and widely used in the food, beverage, and solvent areas. The ethyl acetate production currently proceeds through unsustainable and energy intensive processes, which are based on natural gas and crude oil. Microbial conversion of biomass-derived sugars into ethyl acetate may provide a sustainable alternative. In this review, the perspectives of bio-catalyzing ethanol and acetic acid to ethyl acetate using lipases in vitro was introduced. Besides, the crucial elements for high yield of ethyl acetate in fermentation was expounded. Also, metabolic engineering in yeasts to product ethyl acetate in vivo using alcohol acyl transferases (AAT) was discussed. Key points: •The accumulation of acetyl-CoA is crucial for synthesizing ethyl acetate in vivo; AAT-mediated metabolic engineering could efficiently improve ethyl acetate production.",

keywords = "Alcohol acyl transferases, Bioethanol, Ethyl acetate, Lignocellulose, Lipases",

author = "Shangjie Zhang and Feng Guo and Wei Yan and Weiliang Dong and Jie Zhou and Wenming Zhang and Fengxue Xin and Min Jiang",

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doi = "10.1007/s00253-020-10756-z",

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TY - JOUR

T1 - Perspectives for the microbial production of ethyl acetate

AU - Zhang, Shangjie

AU - Guo, Feng

AU - Yan, Wei

AU - Dong, Weiliang

AU - Zhou, Jie

AU - Zhang, Wenming

AU - Xin, Fengxue

AU - Jiang, Min

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Abstract: Ethyl acetate is one of the short-chain esters and widely used in the food, beverage, and solvent areas. The ethyl acetate production currently proceeds through unsustainable and energy intensive processes, which are based on natural gas and crude oil. Microbial conversion of biomass-derived sugars into ethyl acetate may provide a sustainable alternative. In this review, the perspectives of bio-catalyzing ethanol and acetic acid to ethyl acetate using lipases in vitro was introduced. Besides, the crucial elements for high yield of ethyl acetate in fermentation was expounded. Also, metabolic engineering in yeasts to product ethyl acetate in vivo using alcohol acyl transferases (AAT) was discussed. Key points: •The accumulation of acetyl-CoA is crucial for synthesizing ethyl acetate in vivo; AAT-mediated metabolic engineering could efficiently improve ethyl acetate production.

AB - Abstract: Ethyl acetate is one of the short-chain esters and widely used in the food, beverage, and solvent areas. The ethyl acetate production currently proceeds through unsustainable and energy intensive processes, which are based on natural gas and crude oil. Microbial conversion of biomass-derived sugars into ethyl acetate may provide a sustainable alternative. In this review, the perspectives of bio-catalyzing ethanol and acetic acid to ethyl acetate using lipases in vitro was introduced. Besides, the crucial elements for high yield of ethyl acetate in fermentation was expounded. Also, metabolic engineering in yeasts to product ethyl acetate in vivo using alcohol acyl transferases (AAT) was discussed. Key points: •The accumulation of acetyl-CoA is crucial for synthesizing ethyl acetate in vivo; AAT-mediated metabolic engineering could efficiently improve ethyl acetate production.

KW - Alcohol acyl transferases

KW - Bioethanol

KW - Ethyl acetate

KW - Lignocellulose

KW - Lipases

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M3 - 文献综述

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SN - 0175-7598

VL - 104

SP - 7239

EP - 7245

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

IS - 17

ER -

Perspectives for the microbial production of ethyl acetate

Abstract

Keywords

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