Photoredox-Catalyzed Direct C(sp2)-H Difluoromethylation of Hydrazones with Difluoromethyltriphenylphosphonium Salt via Aminyl Radical/Polar Crossover

Xiao Di Wu, Li Wang, Ji Yu Tao, Zhen Yu Liu, Zeng Liu, Cheng Gao, Dong Ping Shen, Yu Zhang, Li Li Zhao, Kai Zhao

Research output: Contribution to journalArticlepeer-review

Abstract

This study describes an efficacious and generally applicable synthetic strategy for the incorporation of biologically and physiologically prominent difluoromethyl entity into synthetically crucial hydrazone scaffolds with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide. The broad substrate scope, excellent functional group compatibility, feasibility of step and atom economical one-pot synthetic manipulation, and environmentally benign and mild reaction conditions rendered this methodology an efficient tool for the preparation of synthetically and pharmaceutically prominent fluorine-containing imino compounds.

Original languageEnglish
JournalOrganic Letters
DOIs
StateAccepted/In press - 2025

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