TY - JOUR
T1 - Phytic Acid-Promoted rapid fabrication of natural polypeptide coatings for multifunctional applications
AU - He, Xiaodong
AU - Zhang, Jieyu
AU - Xie, Liwei
AU - Sathishkumar, Gnanasekar
AU - Li, Chunmei
AU - Rao, Xi
AU - Zhao, Jing
AU - Zhang, Kai
AU - Wang, Rui
AU - Kang, En Tang
AU - Xu, Liqun
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/7/15
Y1 - 2022/7/15
N2 - Surface modification or reconstruction of biomaterials, medical devices or other materials hold great promise for improved functionality and applications. However, it is essential to develop coating layers possessing a wide range of functionalities, such as antibacterial, anticorrosive and biocompatible properties. In this work, a simplified method was investigated for the supramolecular assembly of natural bio compounds, phytic acid (PA) and antimicrobial peptide of ε-polylysine (Ply), via one-pot co-deposition. The PA and Ply formed a coating layer on the substrate surface through the inherent surface affinity of PA and ionic bond formation between the electro-positive Ply and electro-negative PA. The co-deposition of PA-Ply is a surface-independent. The physio-chemical features of PA-Ply on titanium (Ti) were characterized to reveal the polymer decoration, surface composition, and microtopography. It was noticed that the PA-Ply coating on Ti (Ti-PA-Ply) could kill greater than 99.9% of both Gram-positive and Gram-negative bacterial pathogens upon their adhesion as compared to that of the pristine Ti surface. Furthermore, the in vivo rat subcutaneous infection model demonstrated effective anti-infection and bactericidal properties of the Ti-PA-Ply surface. In addition, the PA-Ply coating exhibited anti-corrosive property for medical-grade magnesium (Mg) in an electrochemical corrosion model, and promoted the proliferation of endothelial cells. The versatile PA-Ply coating also imparted an improved anti-fogging performance. Thus, the present one-step co-depostition of PA-Ply provided a simple, envirementelly-benign and sustainable approach to the design and fabrication of multi-functional surfaces.
AB - Surface modification or reconstruction of biomaterials, medical devices or other materials hold great promise for improved functionality and applications. However, it is essential to develop coating layers possessing a wide range of functionalities, such as antibacterial, anticorrosive and biocompatible properties. In this work, a simplified method was investigated for the supramolecular assembly of natural bio compounds, phytic acid (PA) and antimicrobial peptide of ε-polylysine (Ply), via one-pot co-deposition. The PA and Ply formed a coating layer on the substrate surface through the inherent surface affinity of PA and ionic bond formation between the electro-positive Ply and electro-negative PA. The co-deposition of PA-Ply is a surface-independent. The physio-chemical features of PA-Ply on titanium (Ti) were characterized to reveal the polymer decoration, surface composition, and microtopography. It was noticed that the PA-Ply coating on Ti (Ti-PA-Ply) could kill greater than 99.9% of both Gram-positive and Gram-negative bacterial pathogens upon their adhesion as compared to that of the pristine Ti surface. Furthermore, the in vivo rat subcutaneous infection model demonstrated effective anti-infection and bactericidal properties of the Ti-PA-Ply surface. In addition, the PA-Ply coating exhibited anti-corrosive property for medical-grade magnesium (Mg) in an electrochemical corrosion model, and promoted the proliferation of endothelial cells. The versatile PA-Ply coating also imparted an improved anti-fogging performance. Thus, the present one-step co-depostition of PA-Ply provided a simple, envirementelly-benign and sustainable approach to the design and fabrication of multi-functional surfaces.
KW - Antibacterial
KW - Anticorrosive
KW - Antifogging
KW - Co-deposition
KW - Phytic acid
KW - ε-polylysine
UR - http://www.scopus.com/inward/record.url?scp=85126873779&partnerID=8YFLogxK
U2 - 10.1016/j.cej.2022.135917
DO - 10.1016/j.cej.2022.135917
M3 - 文章
AN - SCOPUS:85126873779
SN - 1385-8947
VL - 440
JO - Chemical Engineering Journal
JF - Chemical Engineering Journal
M1 - 135917
ER -