TY - JOUR
T1 - Polycyclic naphthalenediimide-based nanoparticles for NIR-II fluorescence imaging guided phototherapy
AU - Tang, Chuanchao
AU - Song, Chuanhui
AU - Wei, Zheng
AU - Liang, Chen
AU - Ran, Jianchuan
AU - Cai, Yu
AU - Dong, Xiaochen
AU - Han, Wei
N1 - Publisher Copyright:
© 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Optical imaging and phototherapy in the second near-infrared window (NIR-II, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide (NDI) based chromophore 13-amino-4,5-dibromo-2,7- di(dodecan-6-yl)-1H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone (NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared (NIR) absorption (maximum at 777 nm) and emission (maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles (NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum (maximum at 904 nm) and emission spectrum (maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-II fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention (EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency (30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-II phototheranostic agents possess bright future for clinical NIR-II imaging-guided cancer phototherapy.
AB - Optical imaging and phototherapy in the second near-infrared window (NIR-II, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide (NDI) based chromophore 13-amino-4,5-dibromo-2,7- di(dodecan-6-yl)-1H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone (NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared (NIR) absorption (maximum at 777 nm) and emission (maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles (NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum (maximum at 904 nm) and emission spectrum (maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-II fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention (EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency (30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-II phototheranostic agents possess bright future for clinical NIR-II imaging-guided cancer phototherapy.
KW - fluorescence imaging
KW - phototheranostics
KW - phototherapy
KW - polycyclic naphthalenediimide
KW - second near-infrared window
UR - http://www.scopus.com/inward/record.url?scp=85084516449&partnerID=8YFLogxK
U2 - 10.1007/s11426-020-9723-9
DO - 10.1007/s11426-020-9723-9
M3 - 文章
AN - SCOPUS:85084516449
SN - 1674-7291
VL - 63
SP - 946
EP - 956
JO - Science China Chemistry
JF - Science China Chemistry
IS - 7
ER -
