Practical and general entry to N-tosyl aryl aldimines promoted by sulfamic acid in water and alcohol

Zhenjiang Li; Xinhua Ren; Yuhu Shi; Pingkai Ouyang

doi:10.1080/00397910601131387

Practical and general entry to N-tosyl aryl aldimines promoted by sulfamic acid in water and alcohol

Zhenjiang Li, Xinhua Ren, Yuhu Shi, Pingkai Ouyang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A practical, indirect procedure composed of a three-component condensation using aromatic aldehydes, p-tosylamide, and sodium p-toluenesulfinate in the presence of sulfamic acid in tap water-alcohol solvents to afford amidosulfones, and the subsequent water two-phase basic elimination of the amidosulfones to N-tosyl arylimines, was developed. The process has little environmental impact, easy workup, mild reaction conditions, and good yields and is amenable to large-scale preparations.

Original language	English
Pages (from-to)	713-724
Number of pages	12
Journal	Synthetic Communications
Volume	37
Issue number	5
DOIs	https://doi.org/10.1080/00397910601131387
State	Published - Jan 2007

Keywords

Aqueous solvent
Condensation
Sulfamic acid
Sulfonamide
Sulfonyl imines

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10.1080/00397910601131387

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abstract = "A practical, indirect procedure composed of a three-component condensation using aromatic aldehydes, p-tosylamide, and sodium p-toluenesulfinate in the presence of sulfamic acid in tap water-alcohol solvents to afford amidosulfones, and the subsequent water two-phase basic elimination of the amidosulfones to N-tosyl arylimines, was developed. The process has little environmental impact, easy workup, mild reaction conditions, and good yields and is amenable to large-scale preparations.",

keywords = "Aqueous solvent, Condensation, Sulfamic acid, Sulfonamide, Sulfonyl imines",

author = "Zhenjiang Li and Xinhua Ren and Yuhu Shi and Pingkai Ouyang",

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T1 - Practical and general entry to N-tosyl aryl aldimines promoted by sulfamic acid in water and alcohol

AU - Li, Zhenjiang

AU - Ren, Xinhua

AU - Shi, Yuhu

AU - Ouyang, Pingkai

PY - 2007/1

Y1 - 2007/1

N2 - A practical, indirect procedure composed of a three-component condensation using aromatic aldehydes, p-tosylamide, and sodium p-toluenesulfinate in the presence of sulfamic acid in tap water-alcohol solvents to afford amidosulfones, and the subsequent water two-phase basic elimination of the amidosulfones to N-tosyl arylimines, was developed. The process has little environmental impact, easy workup, mild reaction conditions, and good yields and is amenable to large-scale preparations.

AB - A practical, indirect procedure composed of a three-component condensation using aromatic aldehydes, p-tosylamide, and sodium p-toluenesulfinate in the presence of sulfamic acid in tap water-alcohol solvents to afford amidosulfones, and the subsequent water two-phase basic elimination of the amidosulfones to N-tosyl arylimines, was developed. The process has little environmental impact, easy workup, mild reaction conditions, and good yields and is amenable to large-scale preparations.

KW - Aqueous solvent

KW - Condensation

KW - Sulfamic acid

KW - Sulfonamide

KW - Sulfonyl imines

UR - http://www.scopus.com/inward/record.url?scp=33847125708&partnerID=8YFLogxK

U2 - 10.1080/00397910601131387

DO - 10.1080/00397910601131387

M3 - 文章

AN - SCOPUS:33847125708

SN - 0039-7911

VL - 37

SP - 713

EP - 724

JO - Synthetic Communications

JF - Synthetic Communications

IS - 5

ER -

Practical and general entry to N-tosyl aryl aldimines promoted by sulfamic acid in water and alcohol

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Keywords

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