Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites

X. Miao; W. K. Lim; X. Huang; Y. Chen

doi:10.1016/j.matlet.2005.07.062

Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites

X. Miao, W. K. Lim, X. Huang, Y. Chen

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The purpose of this study was to fabricate composites consisting of three interpenetrating networks: tricalcium phosphate (TCP), hydroxyapatite (HA), and poly(dl-lactide-co-glycolide) (PLGA). The porous TCP network was first produced by coating a polyurethane (PU) foam with hydrolysable alpha-TCP slurry. The HA network was derived from a calcium phosphate cement (CPC) filled in the porous TCP network. The remaining open pore network in the HA/TCP composite was further infiltrated with a PLGA network. The three sets of spatially continuous networks would have different biodegradation rates and thus bone tissue would grow towards the fastest biodegrading network while the remaining networks still maintaining their geometrical shape and carrying the physiological load for the tissue ingrowth.

Original language	English
Pages (from-to)	4000-4005
Number of pages	6
Journal	Materials Letters
Volume	59
Issue number	29-30
DOIs	https://doi.org/10.1016/j.matlet.2005.07.062
State	Published - Dec 2005
Externally published	Yes

Keywords

Calcium phosphate cement
Interpenetrating composite
Poly(dl-lactide-co-glycolide)
Tricalcium phosphate

Access to Document

10.1016/j.matlet.2005.07.062

Cite this

@article{276aa7dda8d341c9bff25a01f7a50244,

title = "Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites",

abstract = "The purpose of this study was to fabricate composites consisting of three interpenetrating networks: tricalcium phosphate (TCP), hydroxyapatite (HA), and poly(dl-lactide-co-glycolide) (PLGA). The porous TCP network was first produced by coating a polyurethane (PU) foam with hydrolysable alpha-TCP slurry. The HA network was derived from a calcium phosphate cement (CPC) filled in the porous TCP network. The remaining open pore network in the HA/TCP composite was further infiltrated with a PLGA network. The three sets of spatially continuous networks would have different biodegradation rates and thus bone tissue would grow towards the fastest biodegrading network while the remaining networks still maintaining their geometrical shape and carrying the physiological load for the tissue ingrowth.",

keywords = "Calcium phosphate cement, Interpenetrating composite, Poly(dl-lactide-co-glycolide), Tricalcium phosphate",

author = "X. Miao and Lim, {W. K.} and X. Huang and Y. Chen",

year = "2005",

month = dec,

doi = "10.1016/j.matlet.2005.07.062",

language = "英语",

volume = "59",

pages = "4000--4005",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

number = "29-30",

}

TY - JOUR

T1 - Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites

AU - Miao, X.

AU - Lim, W. K.

AU - Huang, X.

AU - Chen, Y.

PY - 2005/12

Y1 - 2005/12

N2 - The purpose of this study was to fabricate composites consisting of three interpenetrating networks: tricalcium phosphate (TCP), hydroxyapatite (HA), and poly(dl-lactide-co-glycolide) (PLGA). The porous TCP network was first produced by coating a polyurethane (PU) foam with hydrolysable alpha-TCP slurry. The HA network was derived from a calcium phosphate cement (CPC) filled in the porous TCP network. The remaining open pore network in the HA/TCP composite was further infiltrated with a PLGA network. The three sets of spatially continuous networks would have different biodegradation rates and thus bone tissue would grow towards the fastest biodegrading network while the remaining networks still maintaining their geometrical shape and carrying the physiological load for the tissue ingrowth.

AB - The purpose of this study was to fabricate composites consisting of three interpenetrating networks: tricalcium phosphate (TCP), hydroxyapatite (HA), and poly(dl-lactide-co-glycolide) (PLGA). The porous TCP network was first produced by coating a polyurethane (PU) foam with hydrolysable alpha-TCP slurry. The HA network was derived from a calcium phosphate cement (CPC) filled in the porous TCP network. The remaining open pore network in the HA/TCP composite was further infiltrated with a PLGA network. The three sets of spatially continuous networks would have different biodegradation rates and thus bone tissue would grow towards the fastest biodegrading network while the remaining networks still maintaining their geometrical shape and carrying the physiological load for the tissue ingrowth.

KW - Calcium phosphate cement

KW - Interpenetrating composite

KW - Poly(dl-lactide-co-glycolide)

KW - Tricalcium phosphate

UR - http://www.scopus.com/inward/record.url?scp=26844524309&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2005.07.062

DO - 10.1016/j.matlet.2005.07.062

M3 - 文章

AN - SCOPUS:26844524309

SN - 0167-577X

VL - 59

SP - 4000

EP - 4005

JO - Materials Letters

JF - Materials Letters

IS - 29-30

ER -

Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this