TY - GEN
T1 - Preparation and drug release properties of IBU-loaded mesoporous calcium silicate hydrate (CSH) spheres
AU - Dong, Ya
AU - Yuan, Huiwen
AU - Ni, Yaru
AU - Lu, Chunhua
AU - Xu, Zhongzi
PY - 2012
Y1 - 2012
N2 - The novel kind flowerlike mesoporous spheres of calcium silicate hydrate (CaO•SiO 2•H 2O, CSH) have been synthesized by co-precipitation method on based with water/alcohol/calvital/ tetraethyl orthosilicate (TEOS) system. The synthesized CSH were applied as a carrier to study the loaded behaviors of ibuprofen(IBU),was used to investigate the drug loading behavior of the CSH for different times has been also discussed. The drug loading capacities(DLCs) of CSH loaded for 12h has reached 116.78wt.%. The structural, morphological and textural properties were investigated by SEM, FTIR, TG and BET. The results show that it would be a good candidate as drug carrier for bone repair.
AB - The novel kind flowerlike mesoporous spheres of calcium silicate hydrate (CaO•SiO 2•H 2O, CSH) have been synthesized by co-precipitation method on based with water/alcohol/calvital/ tetraethyl orthosilicate (TEOS) system. The synthesized CSH were applied as a carrier to study the loaded behaviors of ibuprofen(IBU),was used to investigate the drug loading behavior of the CSH for different times has been also discussed. The drug loading capacities(DLCs) of CSH loaded for 12h has reached 116.78wt.%. The structural, morphological and textural properties were investigated by SEM, FTIR, TG and BET. The results show that it would be a good candidate as drug carrier for bone repair.
KW - Calcium silicate hydrate
KW - Drug carrier
KW - Mesoporous
UR - http://www.scopus.com/inward/record.url?scp=84455195539&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMR.393-395.894
DO - 10.4028/www.scientific.net/AMR.393-395.894
M3 - 会议稿件
AN - SCOPUS:84455195539
SN - 9783037853078
T3 - Advanced Materials Research
SP - 894
EP - 897
BT - Biotechnology, Chemical and Materials Engineering
T2 - 2011 International Conference on Biotechnology, Chemical and Materials Engineering, CBCME 2011
Y2 - 28 December 2011 through 29 December 2011
ER -