Abstract
OBJECTIVE: To prepare brevescapine (BRE) inclusion complex freeze-dried powder injection and evaluate its safety. METHODS: BRE-HP-β3-CD inclusion complex was prepared by freeze-dried method using HP-β-CD as inclusion material. The molar ratio between host and guest was optimized by continuing variational method. The inclusion compound was identified by Infrared Spectra (IR) and Differential Scanning Calorimetry (DSC) methods. HPLC was used to determine the solubility of BRE in the inclusion complex. RESULTS: The formulation was prepared and the conclusion molar ratio was 1:2. The solubility was evidently increased and it had no hemolytic and irritant effect. CONCLUSION: Brevescapine inclusion complex freeze-dried powder injection can be prepared by addition of HP-β-CD. The safety is eligible.
| Original language | English |
|---|---|
| Pages (from-to) | 457-460 |
| Number of pages | 4 |
| Journal | Chinese Pharmaceutical Journal |
| Volume | 42 |
| Issue number | 6 |
| State | Published - Mar 2007 |
Keywords
- 2-hydropropyl-β-cyclodextrin
- Brevescapine
- Freeze-dried
- Inclusion complex
- Safety