Prion chemical biology: on the road to therapeutics?

Beining Chen; Mark Thompson; Jennifer Louth; Kai Guo

doi:10.2174/15680266113136660172

Prion chemical biology: on the road to therapeutics?

Beining Chen, Mark Thompson, Jennifer Louth, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

University of Sheffield

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.

Original language	English
Pages (from-to)	2441-2464
Number of pages	24
Journal	Current Topics in Medicinal Chemistry
Volume	13
Issue number	19
DOIs	https://doi.org/10.2174/15680266113136660172
State	Published - 2013

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10.2174/15680266113136660172

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title = "Prion chemical biology: on the road to therapeutics?",

abstract = "Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.",

author = "Beining Chen and Mark Thompson and Jennifer Louth and Kai Guo",

year = "2013",

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AU - Thompson, Mark

AU - Louth, Jennifer

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N2 - Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.

AB - Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.

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M3 - 文献综述

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AN - SCOPUS:84905165161

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JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

IS - 19

ER -

Prion chemical biology: on the road to therapeutics?

Abstract

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