TY - JOUR
T1 - Promiscuous enzyme-catalyzed cascade reaction
T2 - Synthesis of xanthone derivatives
AU - Fu, Yajie
AU - Fan, Bingbing
AU - Chen, Hongyue
AU - Huang, He
AU - Hu, Yi
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/10
Y1 - 2018/10
N2 - Based on the screening of biocatalysts and reaction conditions including organic solvent, water content, lipase loading, reaction temperature and time, lipase TLIM exhibited the prominent promiscuity for the Knoevenagel-Michael cascade reactions of 1, 3-diketones with aromatic aldehydes to synthesize xanthone derivatives. This procedure provides satisfactory advantages such as environmental begin, simple work-up, generality, obtaining in excellent yields (80–97%), and potential for recycling of biocatalyst.
AB - Based on the screening of biocatalysts and reaction conditions including organic solvent, water content, lipase loading, reaction temperature and time, lipase TLIM exhibited the prominent promiscuity for the Knoevenagel-Michael cascade reactions of 1, 3-diketones with aromatic aldehydes to synthesize xanthone derivatives. This procedure provides satisfactory advantages such as environmental begin, simple work-up, generality, obtaining in excellent yields (80–97%), and potential for recycling of biocatalyst.
KW - Aromatic aldehyde
KW - Catalysis
KW - Knoevenagel condensation
KW - Lipase
KW - Xanthone
UR - http://www.scopus.com/inward/record.url?scp=85049771836&partnerID=8YFLogxK
U2 - 10.1016/j.bioorg.2018.06.034
DO - 10.1016/j.bioorg.2018.06.034
M3 - 文章
C2 - 30014923
AN - SCOPUS:85049771836
SN - 0045-2068
VL - 80
SP - 555
EP - 559
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
ER -