Rational design of nanocarriers for mitochondria-targeted drug delivery

Lihua Huang; Zonghao Sun; Qian Shen; Zhongxi Huang; Shuangxi Wang; Naidi Yang; Gongqiang Li; Qiong Wu; Wei Wang; Lin Li; Changmin Yu

doi:10.1016/j.cclet.2022.02.047

Rational design of nanocarriers for mitochondria-targeted drug delivery

Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Naidi Yang, Gongqiang Li, Qiong Wu, Wei Wang, Lin Li, Changmin Yu

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed.

Original language	English
Pages (from-to)	4146-4156
Number of pages	11
Journal	Chinese Chemical Letters
Volume	33
Issue number	9
DOIs	https://doi.org/10.1016/j.cclet.2022.02.047
State	Published - Sep 2022

Keywords

Mitochondria diseases
Mitochondria target
Nanocarriers
Therapeutic drugs

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10.1016/j.cclet.2022.02.047

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title = "Rational design of nanocarriers for mitochondria-targeted drug delivery",

abstract = "Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed.",

keywords = "Mitochondria diseases, Mitochondria target, Nanocarriers, Therapeutic drugs",

author = "Lihua Huang and Zonghao Sun and Qian Shen and Zhongxi Huang and Shuangxi Wang and Naidi Yang and Gongqiang Li and Qiong Wu and Wei Wang and Lin Li and Changmin Yu",

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T1 - Rational design of nanocarriers for mitochondria-targeted drug delivery

AU - Huang, Lihua

AU - Sun, Zonghao

AU - Shen, Qian

AU - Huang, Zhongxi

AU - Wang, Shuangxi

AU - Yang, Naidi

AU - Li, Gongqiang

AU - Wu, Qiong

AU - Wang, Wei

AU - Li, Lin

AU - Yu, Changmin

PY - 2022/9

Y1 - 2022/9

N2 - Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed.

AB - Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed.

KW - Mitochondria diseases

KW - Mitochondria target

KW - Nanocarriers

KW - Therapeutic drugs

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DO - 10.1016/j.cclet.2022.02.047

M3 - 文章

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VL - 33

SP - 4146

EP - 4156

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

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ER -

Rational design of nanocarriers for mitochondria-targeted drug delivery

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Keywords

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