Recent Advancements and Strategies of Improving CO₂ Utilization Efficiency in Bio-Succinic Acid Production

The production of bio-based succinic acid through microbial CO₂ fixation and conversion has gained significant attention as a promising approach to mitigate greenhouse gas emissions. However, the low CO₂ utilization efficiency limits the efficient biosynthesis of succinic acid. Therefore, it is crucial from environmental and economic perspectives to enhance the efficiency of CO₂ utilization in bio-succinic acid production. This review comprehensively covers the introduction of biosynthetic pathways for microbial CO₂ fixation and the conversion of CO₂ to succinic acid, as well as the challenges associated with CO₂ supply and utilization effectiveness. Moreover, strategies including genetic and metabolic engineering for CO₂ fixation, extracellular supply methods of CO₂ and some potential technical approaches for CO₂ capture (such as micro-nano bubbles, CO₂ adsorption material and biofilm) are summarized and presented.