TY - JOUR
T1 - Redox-Sensitive Nanoscale Coordination Polymers for Drug Delivery and Cancer Theranostics
AU - Zhao, Jiayue
AU - Yang, Yu
AU - Han, Xiao
AU - Liang, Chao
AU - Liu, Jingjing
AU - Song, Xuejiao
AU - Ge, Zili
AU - Liu, Zhuang
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/7/19
Y1 - 2017/7/19
N2 - Nanoscale coordination polymers (NCPs), with inherent biodegradability, chemical diversities, and porous structures, are a promising class of nanomaterials in the nanomedicine field. Herein, a unique type of redox-sensitive NCPs is constructed with manganese ions (Mn2+) and dithiodiglycolic acid as the disulfide (SS)-containing organic bridging ligand. The obtained Mn-SS NCPs with a mesoporous structure could be efficiently loaded with doxorubicin (DOX), a chemotherapeutics. The yielded Mn-SS/DOX nanoparticles are coated with a layer of polydopamine (PDA) and then modified by poly(ethylene glycol) (PEG). In such a Mn-SS/DOX@PDA-PEG NCP structure, the disulfide linkage (SS) within dithiodiglycolic acid can be cleaved in the presence of glutathione (GSH), leading to efficient redox-responsive dissociation of NCPs and the subsequent drug release. Meanwhile, Mn2+ in Mn-SS/DOX@PDA-PEG NCPs would offer a strong T1 contrast in magnetic resonance (MR) imaging, Upon intravenous injection, these Mn-SS/DOX@PDA-PEG NCPs show efficient tumor homing, as revealed by MR imaging, and offer an obviously improved in vivo therapeutic outcome compared to that achieved with free DOX.
AB - Nanoscale coordination polymers (NCPs), with inherent biodegradability, chemical diversities, and porous structures, are a promising class of nanomaterials in the nanomedicine field. Herein, a unique type of redox-sensitive NCPs is constructed with manganese ions (Mn2+) and dithiodiglycolic acid as the disulfide (SS)-containing organic bridging ligand. The obtained Mn-SS NCPs with a mesoporous structure could be efficiently loaded with doxorubicin (DOX), a chemotherapeutics. The yielded Mn-SS/DOX nanoparticles are coated with a layer of polydopamine (PDA) and then modified by poly(ethylene glycol) (PEG). In such a Mn-SS/DOX@PDA-PEG NCP structure, the disulfide linkage (SS) within dithiodiglycolic acid can be cleaved in the presence of glutathione (GSH), leading to efficient redox-responsive dissociation of NCPs and the subsequent drug release. Meanwhile, Mn2+ in Mn-SS/DOX@PDA-PEG NCPs would offer a strong T1 contrast in magnetic resonance (MR) imaging, Upon intravenous injection, these Mn-SS/DOX@PDA-PEG NCPs show efficient tumor homing, as revealed by MR imaging, and offer an obviously improved in vivo therapeutic outcome compared to that achieved with free DOX.
KW - chemotherapy
KW - drug delivery
KW - nanoscale coordination polymers (NCPs)
KW - redox-responsive release
KW - theranostics
UR - http://www.scopus.com/inward/record.url?scp=85024919823&partnerID=8YFLogxK
U2 - 10.1021/acsami.7b07535
DO - 10.1021/acsami.7b07535
M3 - 文章
C2 - 28636308
AN - SCOPUS:85024919823
SN - 1944-8244
VL - 9
SP - 23555
EP - 23563
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 28
ER -
