Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

Yao Ding; Shen Yuan Zhang; Yu Chen Chen; Shuai Xin Fan; Jie Sheng Tian; Teck Peng Loh

doi:10.1021/acs.orglett.9b00697

Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

Yao Ding, Shen Yuan Zhang, Yu Chen Chen, Shuai Xin Fan, Jie Sheng Tian, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.

Original language	English
Pages (from-to)	2736-2739
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	8
DOIs	https://doi.org/10.1021/acs.orglett.9b00697
State	Published - 19 Apr 2019

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title = "Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis",

abstract = "A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.",

author = "Yao Ding and Zhang, {Shen Yuan} and Chen, {Yu Chen} and Fan, {Shuai Xin} and Tian, {Jie Sheng} and Loh, {Teck Peng}",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

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T1 - Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

AU - Ding, Yao

AU - Zhang, Shen Yuan

AU - Chen, Yu Chen

AU - Fan, Shuai Xin

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

PY - 2019/4/19

Y1 - 2019/4/19

N2 - A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.

AB - A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.

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U2 - 10.1021/acs.orglett.9b00697

DO - 10.1021/acs.orglett.9b00697

M3 - 文章

C2 - 30920841

AN - SCOPUS:85064136303

SN - 1523-7060

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SP - 2736

EP - 2739

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

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