Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

Hao Qi; Xin Li; Zhuang Liu; Shan Shan Miao; Zheng Fang; Lin Chen; Zheng Fang; Kai Guo

doi:10.1002/slct.201802925

Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

Hao Qi, Xin Li, Zhuang Liu, Shan Shan Miao, Zheng Fang, Lin Chen, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A novel green and efficient reaction route for the synthesis of 2-chloroquinoline via N-fluoride fluorinated by 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.

Original language	English
Pages (from-to)	10689-10693
Number of pages	5
Journal	ChemistrySelect
Volume	3
Issue number	38
DOIs	https://doi.org/10.1002/slct.201802925
State	Published - 17 Oct 2018

Keywords

C2 heterocycle
Halogenation
Microreactor
Nucleophilic substitution
Selectfluor

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10.1002/slct.201802925

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title = "Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor",

abstract = "A novel green and efficient reaction route for the synthesis of 2-chloroquinoline via N-fluoride fluorinated by 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.",

keywords = "C2 heterocycle, Halogenation, Microreactor, Nucleophilic substitution, Selectfluor",

author = "Hao Qi and Xin Li and Zhuang Liu and Miao, {Shan Shan} and Zheng Fang and Lin Chen and Zheng Fang and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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T1 - Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

AU - Qi, Hao

AU - Li, Xin

AU - Liu, Zhuang

AU - Miao, Shan Shan

AU - Fang, Zheng

AU - Chen, Lin

AU - Fang, Zheng

AU - Guo, Kai

PY - 2018/10/17

Y1 - 2018/10/17

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AB - A novel green and efficient reaction route for the synthesis of 2-chloroquinoline via N-fluoride fluorinated by 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.

KW - C2 heterocycle

KW - Halogenation

KW - Microreactor

KW - Nucleophilic substitution

KW - Selectfluor

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M3 - 文章

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SN - 2365-6549

VL - 3

SP - 10689

EP - 10693

JO - ChemistrySelect

JF - ChemistrySelect

IS - 38

ER -

Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

Abstract

Keywords

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