Rhodamine-Ferrocene Conjugate Chemosensor for Selectively Sensing Copper(II) with Multisignals: Chromaticity, Fluorescence, and Electrochemistry and Its Application in Living Cell Imaging

Yuan Fang; Yi Zhou; Qingqing Rui; Cheng Yao

doi:10.1021/acs.organomet.5b00285

Rhodamine-Ferrocene Conjugate Chemosensor for Selectively Sensing Copper(II) with Multisignals: Chromaticity, Fluorescence, and Electrochemistry and Its Application in Living Cell Imaging

Yuan Fang, Yi Zhou, Qingqing Rui, Cheng Yao

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

A ferrocene unit is introduced into the salicylaldehyde Rhodamine 6G hydrazone with an alkynyl group to constitute a new chemosensor, R6G-FC, for specifically sensing Cu²⁺ over other metal ions with multisignals. Upon interaction with Cu²⁺ in aqueous solution, R6G-FC expresses a detectable fluorescence enhancement along with changes in UV-vis absorption spectra and electrochemical parameters due to the binding-induced spirolactam ring-opening process in Rhodamine 6G. The complexation process between R6G-FC and Cu²⁺ can be carried out within a wide pH range in a short response time and with a good reversibility. R6G-FC also exhibits an excellent performance in sensing Cu²⁺ in the "dip-stick" method with an evident color gradation, and confocal fluorescence microscopy imaging results reveal that R6G-FC can be used to visualize Cu²⁺ in living HeLa cells with low cytotoxicity.

Original language	English
Pages (from-to)	2962-2970
Number of pages	9
Journal	Organometallics
Volume	34
Issue number	12
DOIs	https://doi.org/10.1021/acs.organomet.5b00285
State	Published - 22 Jun 2015

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title = "Rhodamine-Ferrocene Conjugate Chemosensor for Selectively Sensing Copper(II) with Multisignals: Chromaticity, Fluorescence, and Electrochemistry and Its Application in Living Cell Imaging",

abstract = "A ferrocene unit is introduced into the salicylaldehyde Rhodamine 6G hydrazone with an alkynyl group to constitute a new chemosensor, R6G-FC, for specifically sensing Cu2+ over other metal ions with multisignals. Upon interaction with Cu2+ in aqueous solution, R6G-FC expresses a detectable fluorescence enhancement along with changes in UV-vis absorption spectra and electrochemical parameters due to the binding-induced spirolactam ring-opening process in Rhodamine 6G. The complexation process between R6G-FC and Cu2+ can be carried out within a wide pH range in a short response time and with a good reversibility. R6G-FC also exhibits an excellent performance in sensing Cu2+ in the {"}dip-stick{"} method with an evident color gradation, and confocal fluorescence microscopy imaging results reveal that R6G-FC can be used to visualize Cu2+ in living HeLa cells with low cytotoxicity.",

author = "Yuan Fang and Yi Zhou and Qingqing Rui and Cheng Yao",

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doi = "10.1021/acs.organomet.5b00285",

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T1 - Rhodamine-Ferrocene Conjugate Chemosensor for Selectively Sensing Copper(II) with Multisignals

T2 - Chromaticity, Fluorescence, and Electrochemistry and Its Application in Living Cell Imaging

AU - Fang, Yuan

AU - Zhou, Yi

AU - Rui, Qingqing

AU - Yao, Cheng

PY - 2015/6/22

Y1 - 2015/6/22

N2 - A ferrocene unit is introduced into the salicylaldehyde Rhodamine 6G hydrazone with an alkynyl group to constitute a new chemosensor, R6G-FC, for specifically sensing Cu2+ over other metal ions with multisignals. Upon interaction with Cu2+ in aqueous solution, R6G-FC expresses a detectable fluorescence enhancement along with changes in UV-vis absorption spectra and electrochemical parameters due to the binding-induced spirolactam ring-opening process in Rhodamine 6G. The complexation process between R6G-FC and Cu2+ can be carried out within a wide pH range in a short response time and with a good reversibility. R6G-FC also exhibits an excellent performance in sensing Cu2+ in the "dip-stick" method with an evident color gradation, and confocal fluorescence microscopy imaging results reveal that R6G-FC can be used to visualize Cu2+ in living HeLa cells with low cytotoxicity.

AB - A ferrocene unit is introduced into the salicylaldehyde Rhodamine 6G hydrazone with an alkynyl group to constitute a new chemosensor, R6G-FC, for specifically sensing Cu2+ over other metal ions with multisignals. Upon interaction with Cu2+ in aqueous solution, R6G-FC expresses a detectable fluorescence enhancement along with changes in UV-vis absorption spectra and electrochemical parameters due to the binding-induced spirolactam ring-opening process in Rhodamine 6G. The complexation process between R6G-FC and Cu2+ can be carried out within a wide pH range in a short response time and with a good reversibility. R6G-FC also exhibits an excellent performance in sensing Cu2+ in the "dip-stick" method with an evident color gradation, and confocal fluorescence microscopy imaging results reveal that R6G-FC can be used to visualize Cu2+ in living HeLa cells with low cytotoxicity.

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ER -

Rhodamine-Ferrocene Conjugate Chemosensor for Selectively Sensing Copper(II) with Multisignals: Chromaticity, Fluorescence, and Electrochemistry and Its Application in Living Cell Imaging

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