Safe and direct conversion of 2,4-Dinitrotoluene into 1-Methyl-2,4-Cyclohexane-Diamine: A One-Pot hydrogenation reaction route catalyzed by Lithium-Modified γ-Al2O3-Supported ruthenium nanoclusters

Xinglin Wen, Yonglu Yang, Yong Pan, Jitao Hu, Xiaoyue Wan, Yanhui Yang, Sébastien Leveneur, Juncheng Jiang

Research output: Contribution to journalArticlepeer-review

Abstract

The hydrogenation of 2,4-dinitrotoluene (2,4-DNT) into 1-methyl-2,4-cyclohexanediamine (2,4-MCHD), a significant yet underutilized raw material for the synthesis of methylcyclohexane diisocyanate (HTDI) with exceptional properties, represents one of the most promising reactions for the development of diisocyanate chemical processes. In this study, we developed a highly efficient and stable heterogeneous catalytic system for the direct hydrogenation of 2,4-DNT to 2,4-MCHD using Li-modified γ-Al2O3 supported Ru nanoclusters (Li-modified-Ru/γ-Al2O3). Under mild reaction conditions, we successfully inhibited side reactions, such as deamination, achieving a selectivity exceeding 95% for 2,4-MCHD, while the conversion of 2,4-DNT surpassed 99%. Kinetic studies revealed that the hydrogenation of 2,4-DNT in this system occurs as a tandem reaction, with the hydrogenation of the benzene ring identified as the rate-determining step. Investigations into the structure–activity relationship indicated that the valence state of the Ru nanocluster, the acid-base properties of the catalyst, the modification by Li, and the synergistic effects of various elements within the catalyst are critical factors contributing to the high activity and stability of the Li-modified-Ru/γ-Al2O3 catalyst for the hydrogenation of 2,4-DNT to produce 2,4-MCHD. This work represents the first example of the direct hydrogenation of dinitroaromatic compounds to yield diamino aliphatic compounds and provides a solid foundation for understanding such reaction systems.

Original languageEnglish
Article number135847
JournalFuel
Volume401
DOIs
StatePublished - 1 Dec 2025

Keywords

  • 1-Methyl-2
  • 2, 4-Dinitrotoluene
  • 4-Cyclohexanediamine
  • Lithium-modified
  • One-Pot Hydrogenation
  • Ruthenium nanocluster

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