Selective single C-F bond arylation of trifluoromethylalkene derivatives

Luning Tang; Ze Yao Liu; Wenzhi She; Chao Feng

doi:10.1039/c9sc01966a

Selective single C-F bond arylation of trifluoromethylalkene derivatives

Luning Tang, Ze Yao Liu, Wenzhi She, Chao Feng

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A strategically novel single C-F bond functionalization of CF₃-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of S_N2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF₃-alkene and arylboronic acid derivatives.

Original language	English
Pages (from-to)	8701-8705
Number of pages	5
Journal	Chemical Science
Volume	10
Issue number	37
DOIs	https://doi.org/10.1039/c9sc01966a
State	Published - 2019

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title = "Selective single C-F bond arylation of trifluoromethylalkene derivatives",

abstract = "A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.",

author = "Luning Tang and Liu, {Ze Yao} and Wenzhi She and Chao Feng",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",

year = "2019",

doi = "10.1039/c9sc01966a",

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T1 - Selective single C-F bond arylation of trifluoromethylalkene derivatives

AU - Tang, Luning

AU - Liu, Ze Yao

AU - She, Wenzhi

AU - Feng, Chao

N1 - Publisher Copyright: © The Royal Society of Chemistry 2019.

PY - 2019

Y1 - 2019

N2 - A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

AB - A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

UR - http://www.scopus.com/inward/record.url?scp=85072706004&partnerID=8YFLogxK

U2 - 10.1039/c9sc01966a

DO - 10.1039/c9sc01966a

M3 - 文章

AN - SCOPUS:85072706004

SN - 2041-6520

VL - 10

SP - 8701

EP - 8705

JO - Chemical Science

JF - Chemical Science

IS - 37

ER -

Selective single C-F bond arylation of trifluoromethylalkene derivatives

Abstract

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