Selenium-functionalized metal-organic frameworks as enzyme mimics

Weiqiang Zhou; Hongfeng Li; Bin Xia; Wenlan Ji; Shaobo Ji; Weina Zhang; Wei Huang; Fengwei Huo; Huaping Xu

doi:10.1007/s12274-017-1623-2

Selenium-functionalized metal-organic frameworks as enzyme mimics

Weiqiang Zhou, Hongfeng Li, Bin Xia, Wenlan Ji, Shaobo Ji, Weina Zhang, Wei Huang, Fengwei Huo, Huaping Xu

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

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43 Scopus citations

Abstract

The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics by grafting selenium-containing molecules (phenylselenylbromide, PhSeBr) to a Zr(IV)-based UiO-66-NH₂ framework. In the presence of glutathione (GSH) serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.

Original language	English
Pages (from-to)	5761-5768
Number of pages	8
Journal	Nano Research
Volume	11
Issue number	10
DOIs	https://doi.org/10.1007/s12274-017-1623-2
State	Published - 1 Oct 2018

Keywords

enzyme mimic
metal-organic frameworks
nano chemistry
postsynthetic modification
selenium chemistry

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title = "Selenium-functionalized metal-organic frameworks as enzyme mimics",

abstract = "The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics by grafting selenium-containing molecules (phenylselenylbromide, PhSeBr) to a Zr(IV)-based UiO-66-NH2 framework. In the presence of glutathione (GSH) serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.",

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author = "Weiqiang Zhou and Hongfeng Li and Bin Xia and Wenlan Ji and Shaobo Ji and Weina Zhang and Wei Huang and Fengwei Huo and Huaping Xu",

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AU - Zhou, Weiqiang

AU - Li, Hongfeng

AU - Xia, Bin

AU - Ji, Wenlan

AU - Ji, Shaobo

AU - Zhang, Weina

AU - Huang, Wei

AU - Huo, Fengwei

AU - Xu, Huaping

PY - 2018/10/1

Y1 - 2018/10/1

N2 - The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics by grafting selenium-containing molecules (phenylselenylbromide, PhSeBr) to a Zr(IV)-based UiO-66-NH2 framework. In the presence of glutathione (GSH) serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.

AB - The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics by grafting selenium-containing molecules (phenylselenylbromide, PhSeBr) to a Zr(IV)-based UiO-66-NH2 framework. In the presence of glutathione (GSH) serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.

KW - enzyme mimic

KW - metal-organic frameworks

KW - nano chemistry

KW - postsynthetic modification

KW - selenium chemistry

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JO - Nano Research

JF - Nano Research

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ER -

Selenium-functionalized metal-organic frameworks as enzyme mimics

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Keywords

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