TY - JOUR
T1 - Self-Assembled Porphyrin-Based Nanoparticles with Enhanced Near-Infrared Absorbance for Fluorescence Imaging and Cancer Photodynamic Therapy
AU - Pan, Dong
AU - Liang, Pingping
AU - Zhong, Xiangmin
AU - Wang, Dong
AU - Cao, Hui
AU - Wang, Wenjun
AU - He, Wanli
AU - Yang, Zhou
AU - Dong, Xiaochen
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/3/18
Y1 - 2019/3/18
N2 - Two novel meso-A2B2-porphyrins (P1 and P2) with symmetrical phenylethynyl groups were synthesized by introducing amphiphilic triethylene glycol moieties onto the parent structure, which improved the near-infrared (NIR) absorbance and resulted in efficient singlet oxygen (1O2) generation. Through solvent-exchange based self-assembly approach, the corresponding hydrophilic nanoparticles (NPs) were fabricated. Thereby, as-prepared NP1 and NP2 presented obvious red-shifted absorbance in NIR region with homogeneous size, superb biocompatibility, higher 1O2 generation, and good phototoxicity as well as low dark cytotoxicity. Furthermore, cellular uptake behavior of the NPs was evaluated by confocal microscopy, which demonstrated that the NPs could easily go through the cell membrane and distribute in cytoplasm with desired fluorescence imaging performance. All results suggest the potential application of the two porphyrin-based NPs in fluorescence imaging guided cancer photodynamic therapy.
AB - Two novel meso-A2B2-porphyrins (P1 and P2) with symmetrical phenylethynyl groups were synthesized by introducing amphiphilic triethylene glycol moieties onto the parent structure, which improved the near-infrared (NIR) absorbance and resulted in efficient singlet oxygen (1O2) generation. Through solvent-exchange based self-assembly approach, the corresponding hydrophilic nanoparticles (NPs) were fabricated. Thereby, as-prepared NP1 and NP2 presented obvious red-shifted absorbance in NIR region with homogeneous size, superb biocompatibility, higher 1O2 generation, and good phototoxicity as well as low dark cytotoxicity. Furthermore, cellular uptake behavior of the NPs was evaluated by confocal microscopy, which demonstrated that the NPs could easily go through the cell membrane and distribute in cytoplasm with desired fluorescence imaging performance. All results suggest the potential application of the two porphyrin-based NPs in fluorescence imaging guided cancer photodynamic therapy.
KW - fluorescence imaging
KW - nanoparticles
KW - photodynamic therapy
KW - porphyrin
UR - http://www.scopus.com/inward/record.url?scp=85069716943&partnerID=8YFLogxK
U2 - 10.1021/acsabm.8b00530
DO - 10.1021/acsabm.8b00530
M3 - 文章
C2 - 35021390
AN - SCOPUS:85069716943
SN - 2576-6422
VL - 2
SP - 999
EP - 1005
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 3
ER -
