Solubility Determination and Thermodynamic Properties of 5-Bromo-2-pyridinecarboxylic Acid in 10 Monosolvents and 3 Binary Solvents at T = (278.15-323.15) K

The static equilibrium method combined with high-performance liquid chromatography was used to determine the solubility of 5-bromo-2-pyridinecarboxylic acid at T = 278.15-323.15 K in 10 monosolvents (methanol, ethyl alcohol, acetonitrile, methyl acetate, ethyl acetate, n-propanol, isopropanol, n-butanol, tetrahydrofuran, and 1,4-dioxane) and 3 kinds of binary solvents (ethyl acetate + tetrahydrofuran, ethyl acetate + methanol, and ethyl acetate + 1,4-dioxane). The results show that 5-bromo-2-pyridinecarboxylic acid is positively related to temperature, and the solubility of 5-bromo-2-pyridinecarboxylic acid in tetrahydrofuran was the highest. In monosolvents, the modified Apelblat model and λh model were used to fit the solubility data of 5-bromo-2-pyridinecarboxylic acid. The solubility data of binary solvents were obtained by combining the nearly ideal binary solvent/Redlich-Kister model and Jouyban-Acree model, which showed that the experimental data were in good agreement with the fitting data. Furthermore, we chose the Kamlet, Abboud, and Taft linear solvation energy relationship model to analyze the relationship between the solute-solvent intermolecular interaction and the solubility of 5-bromo-2-pyridinecarboxylic acid. The results show that the increase of solvent-solvent interaction is beneficial to the dissolution of 5-bromo-2-pyridinecarboxylic acid.