TY - JOUR
T1 - Solubility measurement and thermodynamic modelling of curcumin in twelve pure solvents and three binary solvents at different temperature (T = 278.15–323.15 K)
AU - Cui, Zilong
AU - Yao, Liang
AU - Ye, Jingling
AU - Wang, Zhi
AU - Hu, Yonghong
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/15
Y1 - 2021/9/15
N2 - In the research, the solubility of curcumin was studied by static equilibrium method combined with HPLC. The solubility data of curcumin was measured in twelve pure solvents (dimethyl sulfoxide, tetrahydrofuran, acetone, ethyl acetate, isopropanol, acetonitrile, 1-butanol, ethanol, methanol, xylenes, n-hexane and n-heptane) and three binary solvent mixtures (acetone + tetrahydrofuran, acetonitrile + tetrahydrofuran and n-hexane + tetrahydrofuran) at different temperature (T = 278.15–323.15 K) under atmospheric pressure. The solubility values demonstrate that the solubility increased with the increase of temperature in all solvents. The modified Apelblat model and the Buchowski-Ksiazczak λh model were used to fitted the solubility data in pure solvents, the combined nearly ideal binary solvent/ Redlich-Kister (CNIBS/R-K) model and the Jouyban-Acree model were employed to adopt the solubility data in binary solvent mixtures. The RADmax of the modified Apelblat model and the λh model are 2.621% and 5.831%, the RMSDmax are 6.9 × 10-4 and 1.62 × 10-3, respectively. The RADmax of the CNIBS/R-K model and the Jouyban-Acree model are 2.249% and 4.901%, the RMSDmax are 9.33 × 10-3 and 3.67 × 10-3. Meanwhile, the KAT-LSER model was used to explore the effect of the solvation of curcumin. The fitting results of all equations prove the accuracy of the experimental data, these solubility data are very important for optimizing the extraction process and recrystallization of curcumin.
AB - In the research, the solubility of curcumin was studied by static equilibrium method combined with HPLC. The solubility data of curcumin was measured in twelve pure solvents (dimethyl sulfoxide, tetrahydrofuran, acetone, ethyl acetate, isopropanol, acetonitrile, 1-butanol, ethanol, methanol, xylenes, n-hexane and n-heptane) and three binary solvent mixtures (acetone + tetrahydrofuran, acetonitrile + tetrahydrofuran and n-hexane + tetrahydrofuran) at different temperature (T = 278.15–323.15 K) under atmospheric pressure. The solubility values demonstrate that the solubility increased with the increase of temperature in all solvents. The modified Apelblat model and the Buchowski-Ksiazczak λh model were used to fitted the solubility data in pure solvents, the combined nearly ideal binary solvent/ Redlich-Kister (CNIBS/R-K) model and the Jouyban-Acree model were employed to adopt the solubility data in binary solvent mixtures. The RADmax of the modified Apelblat model and the λh model are 2.621% and 5.831%, the RMSDmax are 6.9 × 10-4 and 1.62 × 10-3, respectively. The RADmax of the CNIBS/R-K model and the Jouyban-Acree model are 2.249% and 4.901%, the RMSDmax are 9.33 × 10-3 and 3.67 × 10-3. Meanwhile, the KAT-LSER model was used to explore the effect of the solvation of curcumin. The fitting results of all equations prove the accuracy of the experimental data, these solubility data are very important for optimizing the extraction process and recrystallization of curcumin.
KW - Curcumin
KW - HPLC
KW - KAT-LSER equation
KW - Solubility
KW - Static equilibrium method
UR - http://www.scopus.com/inward/record.url?scp=85108960019&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2021.116795
DO - 10.1016/j.molliq.2021.116795
M3 - 文章
AN - SCOPUS:85108960019
SN - 0167-7322
VL - 338
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
M1 - 116795
ER -