TY - JOUR
T1 - Solubility of 2-Amino-5-chloro-3-methylbenzoic Acid in Ten Pure Solvents and Three Groups of Binary Mixed Solvents at T = 278.15-323.15 K
AU - Ye, Jingling
AU - Cui, Zilong
AU - Wang, Zhi
AU - Yang, Wenge
AU - Tang, Hanxiao
AU - Chen, Yiyue
AU - Hu, Yonghong
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/6/10
Y1 - 2021/6/10
N2 - In this paper, the solubility of 2-amino-5-chloro-3-methylbenzoic acid under 0.1 MPa atmospheric pressure and temperature T = 278.15-323.15 K was determined by gravimetric analysis. Considering the safety and the cost of solvents, we selected the following 10 pure solvents and three binary mixed solvents: methanol, ethanol, n-butanol, acetone, acetonitrile, ethyl acetate, n-propanol, isopropanol, xylene, and n-hexane (n-hexane + acetone), (acetonitrile + acetone), and (methanol + acetone). The aim is to find suitable solvent systems for the recrystallization of 2-amino-5-chloro-3-methylbenzoic acid. The results indicate that the solubility of 2-amino-5-chloro-3-methylbenzoic acid is positively correlated with temperature, and the solubility of 2-amino-5-chloro-3-methylbenzoic acid is better in acetone. The modified Apelblat model, the Buchowski-Ksiazaczak λh model, the Redlich-Kister (CNIBS/R-K) model, and the Jouyban-Acree model were used to fit the solubility data of 2-amino-5-chloro-3-methylbenzoic acid in different solvents, and the experimental values were in good agreement with the calculated values. By comparing the four models, the modified Apelblat model was found to have a good correlation in pure solvents, and the Redlich-Kister (CNIBS/R-K) model was more suitable than the other two models in binary mixed solvents.
AB - In this paper, the solubility of 2-amino-5-chloro-3-methylbenzoic acid under 0.1 MPa atmospheric pressure and temperature T = 278.15-323.15 K was determined by gravimetric analysis. Considering the safety and the cost of solvents, we selected the following 10 pure solvents and three binary mixed solvents: methanol, ethanol, n-butanol, acetone, acetonitrile, ethyl acetate, n-propanol, isopropanol, xylene, and n-hexane (n-hexane + acetone), (acetonitrile + acetone), and (methanol + acetone). The aim is to find suitable solvent systems for the recrystallization of 2-amino-5-chloro-3-methylbenzoic acid. The results indicate that the solubility of 2-amino-5-chloro-3-methylbenzoic acid is positively correlated with temperature, and the solubility of 2-amino-5-chloro-3-methylbenzoic acid is better in acetone. The modified Apelblat model, the Buchowski-Ksiazaczak λh model, the Redlich-Kister (CNIBS/R-K) model, and the Jouyban-Acree model were used to fit the solubility data of 2-amino-5-chloro-3-methylbenzoic acid in different solvents, and the experimental values were in good agreement with the calculated values. By comparing the four models, the modified Apelblat model was found to have a good correlation in pure solvents, and the Redlich-Kister (CNIBS/R-K) model was more suitable than the other two models in binary mixed solvents.
UR - http://www.scopus.com/inward/record.url?scp=85106365597&partnerID=8YFLogxK
U2 - 10.1021/acs.jced.1c00047
DO - 10.1021/acs.jced.1c00047
M3 - 文章
AN - SCOPUS:85106365597
SN - 0021-9568
VL - 66
SP - 2412
EP - 2424
JO - Journal of Chemical and Engineering Data
JF - Journal of Chemical and Engineering Data
IS - 6
ER -