Solubility of omeprazole sulfide in different solvents at the range of 280.35-319.65 K

Yihua Li; Wenge Yang; Tuan Zhang; Chaoyuan Wang; Kai Wang; Yonghong Hu

doi:10.1007/s10953-013-0110-y

Solubility of omeprazole sulfide in different solvents at the range of 280.35-319.65 K

Yihua Li, Wenge Yang, Tuan Zhang, Chaoyuan Wang, Kai Wang, Yonghong Hu

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van't Hoff equation.

Original language	English
Pages (from-to)	2342-2353
Number of pages	12
Journal	Journal of Solution Chemistry
Volume	42
Issue number	12
DOIs	https://doi.org/10.1007/s10953-013-0110-y
State	Published - Dec 2013

Keywords

Gravimetric method
Omeprazole sulfide
Purification
Solubility
Solution thermodynamics

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10.1007/s10953-013-0110-y

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title = "Solubility of omeprazole sulfide in different solvents at the range of 280.35-319.65 K",

abstract = "Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van't Hoff equation.",

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author = "Yihua Li and Wenge Yang and Tuan Zhang and Chaoyuan Wang and Kai Wang and Yonghong Hu",

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TY - JOUR

T1 - Solubility of omeprazole sulfide in different solvents at the range of 280.35-319.65 K

AU - Li, Yihua

AU - Yang, Wenge

AU - Zhang, Tuan

AU - Wang, Chaoyuan

AU - Wang, Kai

AU - Hu, Yonghong

PY - 2013/12

Y1 - 2013/12

N2 - Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van't Hoff equation.

AB - Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van't Hoff equation.

KW - Gravimetric method

KW - Omeprazole sulfide

KW - Purification

KW - Solubility

KW - Solution thermodynamics

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DO - 10.1007/s10953-013-0110-y

M3 - 文章

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SN - 0095-9782

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JO - Journal of Solution Chemistry

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Solubility of omeprazole sulfide in different solvents at the range of 280.35-319.65 K

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Keywords

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