Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme

Changyu Cao; Nan Yang; Yan Su; Zheye Zhang; Chenxi Wang; Xuejiao Song; Peng Chen; Wenjun Wang; Xiaochen Dong

doi:10.1002/adma.202203236

Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme

Changyu Cao, Nan Yang, Yan Su, Zheye Zhang, Chenxi Wang, Xuejiao Song, Peng Chen, Wenjun Wang, Xiaochen Dong

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper–silver alloy nanoparticle, Cu–Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu–Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically.

Original language	English
Article number	2203236
Journal	Advanced Materials
Volume	34
Issue number	29
DOIs	https://doi.org/10.1002/adma.202203236
State	Published - 21 Jul 2022

Keywords

cytochrome c
ferroptosis
nanozyme
prodrug therapy
starvation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adma.202203236

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abstract = "Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper–silver alloy nanoparticle, Cu–Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu–Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically.",

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T1 - Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme

AU - Cao, Changyu

AU - Yang, Nan

AU - Su, Yan

AU - Zhang, Zheye

AU - Wang, Chenxi

AU - Song, Xuejiao

AU - Chen, Peng

AU - Wang, Wenjun

AU - Dong, Xiaochen

PY - 2022/7/21

Y1 - 2022/7/21

N2 - Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper–silver alloy nanoparticle, Cu–Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu–Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically.

AB - Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper–silver alloy nanoparticle, Cu–Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu–Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically.

KW - cytochrome c

KW - ferroptosis

KW - nanozyme

KW - prodrug therapy

KW - starvation

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Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme

Abstract

Keywords

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