Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

E. J. Corey; Teck Peng Loh; Sidduri AchyuthaRao; Donnette C. Daley; Sepehr Sarshar

doi:10.1021/jo00073a013

Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

E. J. Corey, Teck Peng Loh, Sidduri AchyuthaRao, Donnette C. Daley, Sepehr Sarshar

Harvard University

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.

Original language	English
Pages (from-to)	5600-5602
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	58
Issue number	21
DOIs	https://doi.org/10.1021/jo00073a013
State	Published - 1993
Externally published	Yes

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@article{43fc95db62e14d43944e2f428c4cf24f,

title = "Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine",

abstract = "The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.",

author = "Corey, {E. J.} and Loh, {Teck Peng} and Sidduri AchyuthaRao and Daley, {Donnette C.} and Sepehr Sarshar",

year = "1993",

doi = "10.1021/jo00073a013",

language = "英语",

volume = "58",

pages = "5600--5602",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

AU - Corey, E. J.

AU - Loh, Teck Peng

AU - AchyuthaRao, Sidduri

AU - Daley, Donnette C.

AU - Sarshar, Sepehr

PY - 1993

Y1 - 1993

N2 - The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.

AB - The stereocontrolled total synthesis of the novel analgesic agent (−)-epibatidine (1) and its enantiomer starting with 6-chloropyridine-3-carboxaldehyde (2) has been carried out by way of intermediates 3–10.

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U2 - 10.1021/jo00073a013

DO - 10.1021/jo00073a013

M3 - 文章

AN - SCOPUS:0027442712

SN - 0022-3263

VL - 58

SP - 5600

EP - 5602

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 21

ER -

Stereocontrolled Total Synthesis of (+)- and (−)-Epibatidine

Abstract

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