TY - JOUR
T1 - Structure-controllable Ag aerogel optimized SERS-digital microfluidic platform for ultrasensitive and high-throughput detection of harmful substances
AU - Wang, Zihan
AU - Liu, Wei
AU - Wang, Jie
AU - Huang, Long Jin
AU - Cui, Sheng
AU - He, Xuan
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Miniaturized chips or devices based on surface-enhanced Raman (SERS) technology are an important trend for high-throughput and rapid detection of harmful substances such as explosives in the future. The complementary combination of SERS and digital microfluidics (SERS-DMF) achieves a win-win situation and broadens the application fields of both. However, the noble-metal “hot spots” formed by salt screening in SERS-DMF has the problems of uncontrollable structure and low spatial density, which seriously limits the sensitivity and efficiency of practical application. In this work, structure-controllable Ag aerogel was prepared as a SERS substrate, then combined with digital microfluidics (AgA-DMF) to achieve rapid, high-throughput and ultrasensitive detection of harmful substances. SERS performance of Ag aerogels was optimized by adjusting the structural unit size and aspect ratio. The enhancement factor as high as 4.82 × 107. The AgA-DMF SERS platform detected various harmful substances 2,4,6-trinitrotoluene (TNT, 10−8 M), 3-nitro-1,2,4-triazol-5-one (NTO, 10−9 M) and methylene blue (MB, 10−9 M). The platform streamlined all processes with excellent reaction efficiency and completed high-throughput detection of five samples within 10 min. In addition, the platform integrated portable Raman to realize the detection of real samples. The proposed AgA-DMF platform exhibited rapid, high-throughput and ultrasensitive detection of harmful substances in wastewater, also had considerable potential applications for environmental safety monitoring.
AB - Miniaturized chips or devices based on surface-enhanced Raman (SERS) technology are an important trend for high-throughput and rapid detection of harmful substances such as explosives in the future. The complementary combination of SERS and digital microfluidics (SERS-DMF) achieves a win-win situation and broadens the application fields of both. However, the noble-metal “hot spots” formed by salt screening in SERS-DMF has the problems of uncontrollable structure and low spatial density, which seriously limits the sensitivity and efficiency of practical application. In this work, structure-controllable Ag aerogel was prepared as a SERS substrate, then combined with digital microfluidics (AgA-DMF) to achieve rapid, high-throughput and ultrasensitive detection of harmful substances. SERS performance of Ag aerogels was optimized by adjusting the structural unit size and aspect ratio. The enhancement factor as high as 4.82 × 107. The AgA-DMF SERS platform detected various harmful substances 2,4,6-trinitrotoluene (TNT, 10−8 M), 3-nitro-1,2,4-triazol-5-one (NTO, 10−9 M) and methylene blue (MB, 10−9 M). The platform streamlined all processes with excellent reaction efficiency and completed high-throughput detection of five samples within 10 min. In addition, the platform integrated portable Raman to realize the detection of real samples. The proposed AgA-DMF platform exhibited rapid, high-throughput and ultrasensitive detection of harmful substances in wastewater, also had considerable potential applications for environmental safety monitoring.
KW - Ag aerogel
KW - Digital microfluidic
KW - Explosive molecules
KW - High-throughput detection
KW - Rapid detection
UR - http://www.scopus.com/inward/record.url?scp=85177088212&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2023.134934
DO - 10.1016/j.snb.2023.134934
M3 - 文章
AN - SCOPUS:85177088212
SN - 0925-4005
VL - 401
JO - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
M1 - 134934
ER -