Study on transdermal transfersomes of heparin

Guo Guang Chen; Jun Shou Zhang; Guang Xi Zhai; Zhi Bin Liu; Ping Wei; Ping Kai Ouyang

Study on transdermal transfersomes of heparin

Guo Guang Chen, Jun Shou Zhang, Guang Xi Zhai, Zhi Bin Liu, Ping Wei, Ping Kai Ouyang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

AIM: The purpose is to investigate transdermal transfersomes of heparin. METHODS: Transfersomes were prepared through ultrasonication, and the shape of transfersomes was observed under the electronic microscope. The change of shape was evaluated with the relative velocity through a 0.15 μm micropore film, and the penetration enhancing effect of transfersomes on heparin was tested by the changes of rabbits blood coagulation time. RESULTS: Transfersome particles of heparin were globular or elliptic, their diameter scope was 50-300 nm, the encapsulated ratio of transfersome was 28.7%, and they had a better shape changing property and a significant penetration enhancing effect. CONCLUSION: Transfersome was an excellent transdermal carrier.

Original language	English
Pages (from-to)	110-112
Number of pages	3
Journal	Journal of China Pharmaceutical University
Volume	33
Issue number	2
State	Published - Apr 2002

Keywords

Heparin
Transdermal
Transfersome

Cite this

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title = "Study on transdermal transfersomes of heparin",

abstract = "AIM: The purpose is to investigate transdermal transfersomes of heparin. METHODS: Transfersomes were prepared through ultrasonication, and the shape of transfersomes was observed under the electronic microscope. The change of shape was evaluated with the relative velocity through a 0.15 μm micropore film, and the penetration enhancing effect of transfersomes on heparin was tested by the changes of rabbits blood coagulation time. RESULTS: Transfersome particles of heparin were globular or elliptic, their diameter scope was 50-300 nm, the encapsulated ratio of transfersome was 28.7%, and they had a better shape changing property and a significant penetration enhancing effect. CONCLUSION: Transfersome was an excellent transdermal carrier.",

keywords = "Heparin, Transdermal, Transfersome",

author = "Chen, {Guo Guang} and Zhang, {Jun Shou} and Zhai, {Guang Xi} and Liu, {Zhi Bin} and Ping Wei and Ouyang, {Ping Kai}",

year = "2002",

month = apr,

language = "英语",

volume = "33",

pages = "110--112",

journal = "Journal of China Pharmaceutical University",

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publisher = "China Pharmaceutical University",

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T1 - Study on transdermal transfersomes of heparin

AU - Chen, Guo Guang

AU - Zhang, Jun Shou

AU - Zhai, Guang Xi

AU - Liu, Zhi Bin

AU - Wei, Ping

AU - Ouyang, Ping Kai

PY - 2002/4

Y1 - 2002/4

N2 - AIM: The purpose is to investigate transdermal transfersomes of heparin. METHODS: Transfersomes were prepared through ultrasonication, and the shape of transfersomes was observed under the electronic microscope. The change of shape was evaluated with the relative velocity through a 0.15 μm micropore film, and the penetration enhancing effect of transfersomes on heparin was tested by the changes of rabbits blood coagulation time. RESULTS: Transfersome particles of heparin were globular or elliptic, their diameter scope was 50-300 nm, the encapsulated ratio of transfersome was 28.7%, and they had a better shape changing property and a significant penetration enhancing effect. CONCLUSION: Transfersome was an excellent transdermal carrier.

AB - AIM: The purpose is to investigate transdermal transfersomes of heparin. METHODS: Transfersomes were prepared through ultrasonication, and the shape of transfersomes was observed under the electronic microscope. The change of shape was evaluated with the relative velocity through a 0.15 μm micropore film, and the penetration enhancing effect of transfersomes on heparin was tested by the changes of rabbits blood coagulation time. RESULTS: Transfersome particles of heparin were globular or elliptic, their diameter scope was 50-300 nm, the encapsulated ratio of transfersome was 28.7%, and they had a better shape changing property and a significant penetration enhancing effect. CONCLUSION: Transfersome was an excellent transdermal carrier.

KW - Heparin

KW - Transdermal

KW - Transfersome

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M3 - 文章

AN - SCOPUS:29644441797

SN - 1000-5048

VL - 33

SP - 110

EP - 112

JO - Journal of China Pharmaceutical University

JF - Journal of China Pharmaceutical University

IS - 2

ER -

Study on transdermal transfersomes of heparin

Abstract

Keywords

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