Abstract
A novel approach to α-fluoroamides bearing a C–F quaternary stereocenter is reported herein. With sulfone installed as the activating group, an alkyl group as well as a fluorine atom was introduced successively under mild conditions. Subsequently, heterolytic fission of the C–S bond occurred smoothly under photoredox conditions to afford a tertiary radical, which then engaged in varied intramolecular cyclizations depending on substrate structure and condition applied, rendering sulfone an overall traceless activating group.
Original language | English |
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Pages (from-to) | 96-100 |
Number of pages | 5 |
Journal | Green Synthesis and Catalysis |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2025 |
Keywords
- C–F quaternary stereocenter
- Photoredox
- Sulfone
- Traceless activating group
- α-Fluoroamide